High-precision green transient bio-lithological at the wafer level is realized based on silk protein light chain solution.

Recently, the Chinese Academy of Sciences Shanghai Microsyscules Sensing Technology National Key Laboratory TaoHu Task Force, in conjunction with Fudan University affiliated Huashan Hospital Neurosurgery, Jiangsu University of Science and Technology Silk Industry Research Institute and other research institutions, developed a UV-sensitive and molecular weight of silk protein light chain solution, and based on the solution, combined with traditional ultraviolet lithometry process, to achieve a wafer-level high-precision green transient biometrics.
results of the study were published on Advance Science under the title Precise Protein Photolithography (P3): High Performance Biopatterning Using Silk Fibroin Light Chains the Resist.
silk protein originated from natural silk cocoon, is a kind of natural biological material with excellent technical properties and good biological compatibility, and is widely used in cell culture, tissue engineering and other bio-high-technology fields.
Taohu task force pioneered the separation of silk protein light chain from silk protein, and through chemical modification to make it sensitive to ultraviolet light, to solve the long-term bioprotein material (natural material molecular weight distribution is uneven) as a microner processing material reliability and repeatability is not high, to achieve large-scale silicon chip-level high-precision green bioresisting, can achieve transient biomass patterning and controlled dissolution, successfully achieve high-precision can be customized graphic separation of human fetal nerve stem cells.
this work has been funded by the "Youth Thousands" of the Central Group Department, the Key Research and Development Program of the Ministry of Science and Technology, the National Natural Science Foundation of China, and the Shanghai Science and Technology Commission International Cooperation Program.
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