Highlights of medical and health achievements of national science and technology awards in 2014

Source: reporter of China Medical daily January 9, 2015, the CPC Central Committee and the State Council held a national science and technology award conference in Beijing In 2014, the national science and technology award awarded 318 achievements, 8 science and technology experts and 1 foreign organization 35 medical and health achievements won awards, including 4 National Natural Science Awards, 4 national technology invention awards, 2 first prizes of national science and technology progress awards, 1 innovation team, and 24 second prizes Among them, "China's first effective prevention and control of influenza A (H1N1) pandemic and integrated innovative research", "Chinese patent medicine secondary development core technology system innovation and industrialization" won the first prize of national science and Technology Progress Award; "PLA General Hospital organ injury and repair comprehensive treatment innovation team" became one of the few award-winning innovation teams It is worth mentioning that in 2014, five major national scientific and technological special researches on prevention and control of infectious diseases and six major national scientific and technological special researches on new drug creation won awards The first prize program focused on major issues in April 2009, a new type of influenza suddenly broke out in the world, spread rapidly, and came with fierce force 1.3 billion people in China are facing serious threat Under the leadership of the State Council, a joint prevention and control mechanism led by the former Ministry of health and participated by multiple ministries and commissions has been established Led by Hou Yunde, academician of the Chinese Academy of engineering, "the first effective prevention and control of influenza A (H1N1) pandemic and integrated innovative research in China" Participated by many units in China, including China Center for Disease Control and prevention, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing Center for Disease Control and prevention, etc., and systematically evaluated by a third party led by Professor Xue LAN, Dean of School of public management, Tsinghua University This study proves for the first time that the hypothesis of basic transmission coefficient is correct, that is, in the early stage of epidemic with basic transmission coefficient R0 < 1.8, through medical isolation of infectious sources, it can effectively avoid the peak of epidemic in large cities with concentrated population The implementation of effective isolation measures makes China present a unique epidemic single peak, which is different from the two natural epidemic peaks in other countries and regions, such as Europe and the Americas It is called "China platform" The study also accurately revealed the clinical characteristics and influencing factors of "H1N1", established the largest clinical database of "H1N1" in the world, put forward the "four anti one balance" Li's therapy, significantly reduced the mortality rate, developed the successful diagnostic reagent in the world first, and was adopted by the world Health Organization, and promoted globally The research results greatly reduced the incidence rate and mortality rate of "nail flu" in China The mortality rate is 5 times lower than that of the international community China has never declared a health emergency like other countries, maintaining social stability and economic steady growth How to cultivate high-quality and efficient varieties of traditional Chinese medicine is one of the important problems faced by the development of traditional Chinese medicine industry In this study, we established the clinical positioning technology of Chinese patent medicine based on evidence-based evaluation, the discrimination technology of Chinese patent medicine based on the holistic view, the discrimination technology of Chinese patent medicine quality inspection index based on the characteristics of efficacy and internal process, the multi-level research technology platform of the mechanism of Chinese traditional medicine with systematic pharmacology as the core, and the evaluation method of Chinese traditional medicine efficacy based on network pharmacology The research also pioneered the system engineering technology of traditional Chinese medicine pharmaceutical process, established the analysis, modeling and optimization methods of traditional Chinese medicine pharmaceutical process, systematically identified and comprehensively optimized the pharmaceutical process, established the quality control and optimization technology of traditional Chinese medicine pharmaceutical process, solved the problems of complex chemical components of traditional Chinese Medicine, unclear relationship between process parameters and drug quality, and proposed the quality control theory of traditional Chinese medicine pharmaceutical process On the other hand, the "three in one" whole process quality control technology is established, which integrates the quality control of traditional Chinese medicine, the quality control of pharmaceutical process and the quality control of pharmaceutical process The research has completed the secondary development of dozens of varieties of Chinese patent medicine, which has increased the sales of over 100 million yuan varieties from 3 to 12 The project technology has been popularized in 19 provinces and cities, applied to nearly 100 traditional Chinese medicine enterprises, cultivated a large variety group of traditional Chinese medicine, led the innovation and development direction of traditional Chinese medicine industry, and promoted the technology upgrading of traditional Chinese medicine industry In 2014, 5 major national science and technology projects for infectious disease prevention and control won the national science and technology award One first prize of national science and Technology Progress Award: "China's first effective prevention and control of influenza A (H1N1) pandemic in 2009 and integrated innovative research"; two second prizes of National Natural Science Award: "functional nucleic acid molecular recognition and biosensor method research", "new mechanism of tissue immune microenvironment promoting human liver cancer progress"; two second prizes of national science and Technology Progress Award:“ The key technologies and applications of multi-functional molecular imaging in tumor diagnosis and treatment, and the innovation and application of the key technology system to improve the surgical efficacy of liver cancer Professor Tan Weihong, Hunan University, is responsible for the research of "functional nucleic acid molecular recognition and biosensor method", which focuses on the key problem that the sensitivity and selectivity of nucleic acid sensor in complex environmental life system are limited Using functional nucleic acids such as aptamers as molecular tools, from inorganic nanomaterials to fluorescent signal conversion, nucleic acid molecular circulation/ Amplification of detection signal by chain biological reaction and hybridization near the surface of nucleic acid to improve the signal to back ratio by 3 A series of new principles and methods for signal conversion and amplification of nucleic acid sensors have been put forward and established, which solve the problem that traditional nucleic acid probes are difficult to meet the complex and highly sensitive detection of trace biological samples, and make our country occupy a place in the international nucleic acid sensing field The enzyme-linked oligonucleotide assay (ELONA) constructed by the research results can detect HCV core protein with content lower than 22.5 pg / ml in tens of minutes, and the positive rate of serum core protein in patients with hepatitis C can reach 93.4% Tissue immune microenvironment can significantly affect the progress of tumor, which is an important target of tumor prevention and treatment However, in the past, the study of tumor immunity usually focused on the tissue as a whole and immunosuppression The project "the new mechanism of tissue immune microenvironment promoting the development of human hepatocarcinoma", which was presided over by Professor Zheng Limin of Sun Yat sen University, was carried out in combination with clinical samples and experimental models of hepatocarcinoma It was found that tumor can use immune cells to migrate in tissues/ The time and space characteristics of differentiation are used to educate them dynamically, so that immune cells show unique distribution and function in different regions of liver cancer Besides immunosuppression, tumors will also use "immune activation" to help their progress, and identify important molecules regulating immune and tumor cell functions in multiple tissue microenvironments "Key technology and application of multifunctional molecular imaging tumor diagnosis and treatment" jointly completed by Harbin Medical University, Shanghai Jiaotong University and other units The principle and method of rapid and large-scale controllable synthesis of metal nanoparticles are put forward, the technical method and process of surface functional modification of nanoparticles and coupling with antibodies are established, and a series of nanoprobes of nanoparticle labeled antibodies are designed and developed innovatively; the in vivo, location and quantitative visualization of key molecular targets of malignant tumors are realized, which is the molecular target of malignant tumors On this basis, a new nano delivery carrier platform for tumor treatment was developed, which can efficiently carry antisense nucleic acids, siRNA, microRNA, drugs and other drugs into target cancer cells, play a therapeutic role, and provide a new means for molecular level treatment The project team led by Professor Shen Feng of Dongfang hepatobiliary surgery hospital, together with the main clinical centers of liver cancer in China, completed the research of "innovation and application of key technical system to improve the surgical efficacy of liver cancer" under the support of national science and technology major projects, found the pathogenesis of intrahepatic cholangiocarcinoma, created a new standard of surgical prognosis, established a new plan for prevention and treatment of recurrence of liver cancer, and proposed The new concept of "inflammatory cancer" prevention and treatment The results of this study have great clinical application value The overall 5-year survival rate of patients increased from 45.5% to 53.2% The major new drug creation project has won quite a lot The major national new drug creation project has won 6 national science and technology progress awards in 2014, including 1 first prize: "creation, research and industrialization of core technology system for secondary development of Chinese patent medicine"; 5 second prizes: "key technologies and Applications for identification and acquisition of trace active substances in Chinese herbal medicine"“ Research on the basis and application of tiaogan qishuhuazhuo method in the prevention and treatment of disorders of glucose and lipid metabolism, research and application of the site conditions for the production of traditional Chinese medicine and the remediation technology of soil micro ecological environment, construction and application of the pharmacodynamic evaluation system of traditional Chinese medicine derived from the clinical practice of traditional Chinese medicine, key technology and industrialization of the production of acarbose raw materials and preparations The research on "key technology and application of identification and acquisition of trace active substances in Chinese herbal medicine" was jointly completed by Institute of medicine, Chinese Academy of Medical Sciences and Beijing Kelaibo Pharmaceutical Development Co., Ltd The project has established a new technology system for the identification, acquisition and evaluation of micro active substances, overcome the technical bottleneck of micro active substances research; obtained a batch of new high active micro ingredients by using the new technology system, selected a number of candidate new drugs with unique functions, obtained a clinical research approval, and realized technology transfer of three innovative drugs; 10 The application of this technology in traditional Chinese medicine enterprises solved the technical problems that were difficult to solve in the past and improved the product quality "Basic and applied research on the prevention and treatment of disorders of glucose and lipid metabolism by the method of regulating liver, activating pivot and turbidimetry" completed by Guangdong Pharmaceutical College, Baiyunshan, Guangzhou and Huangpu traditional Chinese Medicine Co., Ltd Break through the restriction of unclear material basis and mechanism of traditional Chinese medicine in the treatment of single disease of glycolipid metabolism, take the lead in the overall understanding and comprehensive treatment of it, find out the key role of liver in the pathogenesis of glycolipid metabolism disease, and first propose "regulating liver, promoting pivot and turbidity" Methods, and developed innovative Chinese medicine with clear composition and mechanism, which has comprehensive regulatory functions such as hypoglycemic, lipid-lowering, anti-inflammatory, endothelial protection and so on; built an international advanced research and development platform of Integrated Chinese and Western medicine for glycolipid metabolism disease, and found for the first time that insulin resistance is independent of fat and AT1 signal; found for the first time that high cholesterol accelerates vitamin D2 The new mechanism of inducing vascular calcification affects the diet of American people, and this research is at the international leading level "Research and application of the site conditions of Chinese herbal medicine production and soil micro ecological environment remediation technology" completed by scientists from Institute of traditional Chinese medicine, Chinese Academy of Chinese medicine, Zhejiang University and other units In view of the problems of heavy metal pollution and continuous cropping obstacles in the soil of traditional Chinese medicine cultivation, a variety of important traditional Chinese medicine materials with high requirements for site conditions, suitable land shortage and serious continuous cropping obstacles were selected, and systematic exploration and research were carried out on the key common technologies such as comprehensive treatment of agricultural heavy metal in the soil of traditional Chinese medicine cultivation, reduction of self toxicity of continuous cropping, nutrient balance, etc As the ecological restoration of soil, the index system of comprehensive evaluation of soil fertility and mycorrhizal cultivation technology system of traditional Chinese medicine were established, and the service platform of ecological research technology of traditional Chinese medicine resources was formed, and a series of societies were formed