Highly active cell inoculation corneal lenses are expected to "re-build" the retina

, Beijing, July 17 (Reporter Li Wei) elderly macular degeneration, retinal pigment degeneration and other retinal degenerative diseases, so far there is no effective treatment, is recognized as a "vision killer." Professor Chen Jiansu, Professor
Tang Shibo of Central South University and Deputy Director of the Eyre Eye Research Institute, led the team to cultivate RPE cells with strong proliferation capacity, high activity and good function by using the induced pluripotent stem cell (iPS) conditional medium, bringing hope for the treatment of blinding diseases such as retinal degeneration.
The study was supported by the Hunan Science and Technology Innovation Program, and the paper "Research on building highly active retinal pigment epithelial cells (RPEs) using iPS conditional cultures and fly-second corneal lenses" was recently published online in the Journal of Biomass.
retina is a photoresponsive tissue inside the back wall of the eye, a soft, transparent film. The human eyeball is like a camera, the retina is the equivalent of a photosensive substrate, responsible for photosensic and image formation, retinal lesions may lead to permanent loss of vision. Retinal degenerative disease is one of the most common ophthalmological diseases in China over 50 years of age, with more than 30 million cases.
Tang Shibo team found that factors such as plate-derived growth factor AA (PDGF-AA), insulin-like growth factor binding protein 2 (IGFBP-2) in the culture of iPS cell condition can obtain a large number of highly active RPE cells; The study also found that patients' urine, somatic cells in the blood, and their conversion into iPS stem cells, and induced the production of RPE cells, which form a thin layer of flaky tissue similar to the natural structure of the retina, and then transplant the flaky tissue behind the patient's retina in order to repair the patient's vision. Since iPS stem cells originate from the patient's autologic cells, the immune rejection of allogeneic cell transplantation is avoided.
research team will also be full-flying second laser myopia surgery cut corneal substring lens "waste for treasure", RPE cells inoculated in corneal substring lens, the application of iPS condition culture, can make RPE cell slices with more stem cell properties, perfect fiber assembly and other functions.