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    Home > Biochemistry News > Biotechnology News > Histone citrullination: a new target for tumor therapy

    Histone citrullination: a new target for tumor therapy

    • Last Update: 2021-08-06
    • Source: Internet
    • Author: User
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    Histone, as the main protein component of chromatin, as the reel that wraps around DNA, plays a central role in gene regulation


    Nucleosomes are the basic unit of chromatin, composed of central histones and packaged DNA


    After DNA damage, the H2A variant H2A.


    Structure of PAD1, PAD2, PAD3 and PAD4

    Image source: https://doi.


    In general, histone citrullination has received more and more attention because of its important significance under both pathological and physiological conditions


    Epigenetic modifications complement classical genetics, and modifications involving PAD-mediated histone citrullination play an indispensable role in physiology and tumors


    references

    Dongwei Zhu et al.


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