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Histone, as the main protein component of chromatin, as the reel that wraps around DNA, plays a central role in gene regulation
Nucleosomes are the basic unit of chromatin, composed of central histones and packaged DNA
After DNA damage, the H2A variant H2A.
Structure of PAD1, PAD2, PAD3 and PAD4
Image source: https://doi.
In general, histone citrullination has received more and more attention because of its important significance under both pathological and physiological conditions
Epigenetic modifications complement classical genetics, and modifications involving PAD-mediated histone citrullination play an indispensable role in physiology and tumors
references
Dongwei Zhu et al.