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Recently, the research results of the Tan Anjiang Research Group and Huang Yongping Research Group of the Center for Excellence in Molecular Plant Sciences of the Chinese Academy of Sciences and the Huang Yongping Research Group were published online in PLOS Genetics under the title Oftyxmori histone methyltransferase BmAsh2 is essential for piere-mediated sex siwei.
the study reported on the molecular mechanism of histone methylated transferase Ash2 to regulate the sex of silkworms.
gender decision is an important physiological process of organisms, regulated by cascading reactions, and the gender decision mechanism of different insects is highly diverse.
silkworm chromosomal system is ZZ/ZW type, female individual is heterotype matchmaker ZW, male individual is the same type matchmaker ZZ.
has found that Fem piRNA on the W chromosome is the initiation factor of the sex decision of silkworms, however, the mechanism of sex decision mechanism of piRNA regulation of silkworms needs to be studied in depth.
the study first obtained a mutation of the silkworm piRNA binding protein Siwi through the CRISPR/Cas9 system. Further research
found that the silkworm protein methylater ash2 was specifically regulated by the piRNA binding protein Siwi, whose expression was lowered in The Siwi mutants.
Ash2 and Siwi mutants both exhibited the characteristics of female individual maleization, revealing that Ash2 and Siwi played a similar role in the gender decision mechanism of the silkworms.
the expression and tissue location of The Siwi protein in Ash2 mutants were not affected, indicating that Ash2 did not function as an upstream factor for Siwi.
immunocoprecipitation results confirmed that Ash2 can be directly combined with Siwi protein, suggesting that Ash2 can participate in the gender decision of silkworms as Siwi's co-factor.
the study revealed that the silkworm protein methylation pathway was involved in piRNA-mediated gender decisions, further clarifying the gender decision mechanism of silkworms. the first author of the
thesis is Li Zhixuan, an assistant researcher in Huang Yongping's research group, and The communication author is researcher Tan Anjiang.
research work has been supported by the National Natural Science Foundation of China and the Chinese Academy of Sciences.
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