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HIV infection: a better understanding of the virus pool in the body

 Last Update: 2022-01-09
 Source: Internet
 Author: User

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CD4+ T cells are an important part of the immune system and play a key role in protecting the body against pathogens
.

Because they have a variety of defense mechanisms against HIV in the resting state, they are rarely infected-but the few infected cells form a latent reservoir of HIV in the body, which currently cannot be reached by antiviral drugs

Quiescent CD4+ T cells are hardly adapted to genetic manipulation, because existing methods usually assume cell division, Keppler explained
.

"Static cells do not divide by definition

In the future, researchers will be able to eliminate individual genes and entire signaling pathways and analyze their functions
.

By knocking out the corresponding genes, they have managed to figure out whether four previously controversial cytokines play a role in HIV infection

On this basis, they sought a second "knock-in" method, that is, inserting additional or slightly modified genes, such as the green fluorescent protein (GFP) gene
.

With the help of this protein, researchers can analyze changes in the activity of target genes under specific conditions, or label specific proteins

Journal Reference :

Manuel Albanese, Adrian Ruhle, Jennifer Mittermaier, Ernesto Mejías-Pérez, Madeleine Gapp, Andreas Linder, Niklas A.

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