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    Home > Biochemistry News > Biotechnology News > Hong Kong University of Science and Technology's latest article: Using whole-brain genome editing technology to treat Alzheimer's disease

    Hong Kong University of Science and Technology's latest article: Using whole-brain genome editing technology to treat Alzheimer's disease

    • Last Update: 2021-08-27
    • Source: Internet
    • Author: User
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    Photo: Professor Ye Yuru (second from right), the vice president of research and development at the Hong Kong University of Science and Technology, and his research team members used a confocal imaging system (pictured) to demonstrate how genome editing strategies can reduce the destructive effects of familial Alzheimer's disease mutations


    Source: Hong Kong University of Science and Technology

    An international research team led by scientists from the Hong Kong University of Science and Technology (HKUST) has developed a new strategy that uses whole-brain genome editing technology to reduce Alzheimer's disease (AD) pathology in genetically modified AD mouse models


    In China alone, it is estimated that more than 500,000 patients suffer from hereditary AD-familial Alzheimer's disease (FAD), which is a congenital AD that is highly correlated with family history


    The use of genome editing technology as a strategy to treat diseases caused by genetic mutations (such as FAD) has great potential


    Recently, a research team led by Professor Ye Yuru of the Hong Kong University of Science and Technology has developed a new genome editing system that can not only penetrate the blood-brain barrier, but also deliver optimized genome editing tools to the entire brain


    At the same time, the research team also found that in the mouse model, the level of amyloid is still very low 6 months after treatment (about 1/3 of their normal lifespan), indicating this single genome editing Strategy has a lasting impact


    Professor Ye said: "This is the first effective brain genome editing technology that can relieve the symptoms of Alzheimer's disease in the entire brain.


    This research is the result of joint efforts of scientists from the Hong Kong University of Science and Technology, California Institute of Technology and Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences


    Original search:

    Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer's disease alleviates amyloid-related pathologies in mice

    DOI 10.


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