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    Home > Active Ingredient News > Infection > How can HIV infection prevention be scaled up? AIDS 2022 blockbuster research analysis

    How can HIV infection prevention be scaled up? AIDS 2022 blockbuster research analysis

    • Last Update: 2022-10-20
    • Source: Internet
    • Author: User
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    For medical professionals only

    , multi-channel publicity, increased screening, intervention of key populations, community participation and other measures can help prevent HIV infection
    .




    At present, the situation of human immunodeficiency virus (HIV) infection has improved, but it is still far
    from the "three 95%" goal by 2030.
    The reason is that in addition to the urgent popularization of routine behavioral interventions such as knowledge education, condom promotion, and HIV testing applications, the awareness rate and use rate of pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) are still not ideal
    .


    In order to further help the clinical prevention of HIV infection, the "HIV Drug Prevention Academic Live Broadcast Conference - 2022 AIDS Prevention Express" sponsored by the AIDS Drug Prevention and Blocking Professional Committee of the China Association for STD and AIDS Prevention and Control was officially launched
    on September 30, 2022.
    The conference was jointly broadcast by 5 platforms, with a cumulative number of views of more than 20,000 times, and many experts gathered together to share an academic feast
    .


    Group photo of experts at the HIV drug prevention academic live broadcast meeting








    AIDS 2022 prevention-related blockbuster research results express


    The AIDS 2022 Prevention Express Forum was chaired
    by Professor Wang Hui of Shenzhen Third People's Hospital.
    Professor Wang Hui opened by saying that it is usually the peak time for HIV prevention counselors to visit AIDS clinics on holidays or the end of holidays, so it is timely to hold this academic live broadcast before welcoming the National Day
    .


    Figure Professor Wang Hui, Chairman of the Conference


    • 2022 International AIDS Conference Express - New progress and blockbuster research analysis in the field of HIV prevention


    Professor Jiang Honglin of Hubei Provincial Center for Disease Control and Prevention delivered the first speech
    .


    Figure Professor Jiang Honglin


    Professor Zhao Qingxia of Henan Provincial Hospital of Infectious Diseases summarized the current global progress of HIV prevention from two aspects: prevention status and prevention experience, and analyzed a number of blockbuster studies
    on HIV prevention.
    By interpreting studies in the United States, Canada, and China, Professor Zhao Qingxia pointed out that the awareness, acceptance, and willingness to use PrEP are generally low
    .
    In terms of prevention experience, in addition to launching PrEP (USA) on the same day, focusing on frequency and effectiveness (Peru), and differentiating, de-medicalization, and simplifying PrEP (Vietnam), AIDS 2022 also proposed Chinese HIV prevention strategies
    such as multi-channel intervention, increased screening, key population intervention, and community participation.
    Studies have confirmed that PrEP during pregnancy has no adverse effects on children's growth indexes and neurodevelopmental indicators, and can significantly reduce the risk of
    HIV infection.
    It is recommended to recommend
    fewer adverse events than Kernpreno tablets as a PEP regimen, good safety, high subject compliance and full completion.


    Figure Professor Zhao Qingxia


    • Monolithic blocking keeps pace with the times


    Professor Sun Lijun of Beijing You'an Hospital affiliated to Capital Medical University then took over the baton and introduced the content of the next session and the speakers
    .


    Figure Professor Sun Lijun


    Professor Chen Yaokai of Chongqing Public Health Medical Treatment Center introduced the concept, classification and preventive use of PrEP and PEP in detail, and proposed that pre- and post-exposure HIV prophylaxis is an effective way to
    reduce the risk of HIV infection.
    China's PEP awareness, utilization rate, and completion rate are low, and a simple, safe, well-tolerated and cost-effective single-chip blocking program is the way to
    break the current situation of HIV prevention.
    Therefore, the 2021 edition of the "Chinese AIDS Diagnosis and Treatment Guidelines" for the first time proposed a complete antiviral triple monotablet composed of powerful backbone drugs and innovative integrase inhibitors, Bikenpreno tablets, which can be recommended as a PEP regimen
    .
    Counselors within 72 hours of exposure to HIV should take one bikernpreno tablet daily for 28 days
    , according to guidelines.
    Counselors with PEP ≥ twice a year, or those with persistent HIV exposure, should recommend PrEP.


    Figure Professor Chen Yaokai


    • Drug prevention case sharing and review


    The third speech was moderated
    by Professor Chen Lin, Institute of AIDS and STD Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention.


    Figure Professor Chen Lin


    Director Li Jin of Dongguan Ninth People's Hospital first interpreted the changes in the number of non-occupational post-exposure prophylaxis (nPEP) counselors and standardized follow-up, pointing out that although the number of HIV prevention counselors has increased year by year, the number of follow-up is less than 50%, and improving follow-up compliance is the key to
    PEP.
    Later, Director Li Jin shared two cases
    of men who have sex with men (MSM) who purchased PEP drugs for irregular treatment after high-risk sexual behavior, resulting in drug-resistant sites.
    Two patients were given BIKENPRENO tablets for PEP after developing drug resistance, and follow-up showed that the regimen was highly effective in reducing HIV viral load, had a good safety profile, and the weight of the counselor did not change much
    after taking it.
    Finally, Director Li Jin concluded that drug resistance is a challenge for global HIV treatment and prevention, and non-standard PEP can easily lead to drug resistance, which ultimately affects the choice of
    antiviral regimens.
    Bikernpreol tablets are potent and rapid, and the incidence of drug resistance is low, which can be recommended as the preferred regimen
    for PEP.


    Figure Director Li Jin


    • Question discussion session


    Finally, Director Zhang Lukun of Shenzhen Third People's Hospital presided over the discussion session
    .


    Director Zhang Lukun


    In the Q&A session, experts discussed and answered
    a number of cutting-edge questions raised by the audience.
    First of all, Director Wang Hui put forward the main problems
    that still exist in China's HIV prevention from the aspects of "people" and "places".


    On the "human" side, the awareness rate of HIV drug prevention among medical staff in all departments is generally low
    .
    At present, the infectious disease department of the hospital is mainly responsible for HIV drug prevention, and the emergency department and other departments are the main departments for consultation, and the awareness rate of medical staff about HIV drug prevention needs to be improved
    .
    In addition, the awareness rate of drug prevention among people at potential high risk of HIV infection, such as MSM, has increased in the past two years, but it has not reached a satisfactory level
    .

    In terms of "places", most of the people who need HIV drug prevention are needed, especially high-risk groups who need PrEP are reluctant to go to the hospital to start standardized prevention because they are afraid of being misunderstood and discriminated against, worried about affecting social interaction, etc.
    , which has led to many high-risk groups not being clinically detected
    .
    Most of these high-risk groups buy drugs online and open PrEP/PEP on their own, so how to do a good job of supervision and testing on the Internet is also a major issue
    in HIV drug prevention.
    Professor Wang Hui pointed out that hospitals, CDC and community organizations can work together to do a good job in
    HIV drug prevention.






    Regarding how to optimize the cross-departmental cooperation mechanism such as clinical and disease control, Professor Jiang Honglin put forward the following key points: 1.
    HIV drug prevention should set appropriate indicators, such as government, clinical, and community organizations should have clear goals and consensus on the prevalence of HIV drug prevention, and then achieve the prevention goals step by step and step by step; 2.
    Actively set up community HIV prevention points and provide consultation and testing services; 3.
    In addition to publicizing and promoting drug prevention related knowledge, condoms, HIV testing and other promotion work should be implemented simultaneously; 4.
    Realize free drugs, do a good job in privacy protection, and ensure that HIV prevention counselors adhere to follow-up
    .


    At the end of the discussion, Professor Sun Lijun once again emphasized that the characteristics of different types of high-risk groups of HIV infection (gay men, opposite sex, etc.
    ) should be increased to let counselors better understand and accept HIV drug prevention programs
    .


    Figure Expert discussion session


    brief summary



    So far, the HIV Drug Prevention Academic Live Session (2022) - 2022 AIDS Prevention Express Forum has come to a
    successful end.
    At present, there are still many problems in HIV pre- and post-exposure prevention in China, mainly manifested as the low awareness rate of PrEP among medical staff, and the low
    awareness, acceptance, utilization rate and completion rate of PrEP and PEP among people at potential high risk of HIV infection.
    People at high risk who know and receive HIV drug prevention often lead to prevention failure or even drug resistance due to self-medication
    .


    A series of studies reported at AIDS 2022 confirmed that multi-channel intervention, increased screening, key population intervention, community participation, and same-day activation can help clinical HIV infection prevention
    .
    In terms of drugs, it has fewer adverse events, good safety, high subject compliance and full completion than the single-tablet PEP regimen of Kernpreno, which is the only single-tablet PEP regimen
    recommended in the 2021 edition of the Chinese AIDS Diagnosis and Treatment Guidelines.


    This information is for medical and scientific reference only and is not recommended for use of this product in any manner that does not correspond to the approved prescription information in your country.

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