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Mistakes in mitochondrial metabolism lead to various diseases, such as Parkinson's and Alzheimer's
Look at developmental disorders from a new perspective
DYRK1A is defective in neurodevelopmental disorders such as autism, microcephaly, and Down syndrome
"For a long time, researchers believed that the TOM complex is a rigid structure in the mitochondrial membrane, and its door is always open," Meisinger explained
DYRK1A acts on the TOM complex
The first authors of the study, Dr.
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Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery