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    Home > Biochemistry News > Biotechnology News > How cells control their boundaries

    How cells control their boundaries

    • Last Update: 2022-04-23
    • Source: Internet
    • Author: User
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    Image: Combining stopped-flow dynamics measurements with molecular dynamics simulations revealed molecular details of the passage of small polar compounds (water and lactate) through a model cell membrane


    Bacteria, fungi, and yeast are very good at excreting useful substances, such as weak acids


    Boundary control is very important for cells


    synthetic vesicles

    This is a problem for the biotech industry, which uses cells as factories to produce large quantities of useful substances, and these working cells are required to survive harsh conditions, such as high concentrations of alcohol or weak acids


    So he combined these two questions in a research project


    Adjustment

    The fatty acid tails of lipids have the greatest effect on membrane properties, while hydrophilic headgroups have little effect on membrane permeability


    Therefore, Poolman and his colleagues defined variables that alter the membrane permeability of different classes of compounds


    drug design

    An increased understanding of the physical processes that affect permeability could help companies understand why certain cells are better suited to specific processes than others


    Another application is the design of intracellularly acting drugs


    article title

    Membrane thickness, lipid phase and sterol type are factors that determine membrane permeability to small solutes


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