-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
How do bacteria infect the host? |
Researchers discover new ways to regulate bacterial infection behavior |
Schematic diagram of optogenetic method for controlling the pathogenicity of bacteria in the host.
Can you imagine that the total number of bacteria in an adult is 100 trillion?
The large number and variety of bacteria are the pathogens of many diseases, and they can be infected by contact, digestive tract, respiratory tract, insect bites and other transmission methods.
For the prevention of human diseases, it is important to understand how bacteria infect the human body and further regulate the behavior of bacterial infections.
) The research results of the Jin Fan team and Huang Zhuqiang team of the Institute of Synthetic Biology on bacterial infections were published in ACS Synthetic Biology in the form of a cover article .
How do bacteria infect the host?
Bacterial infections often present both acute and chronic modes.
The research team selected a common opportunistic pathogen-Pseudomonas aeruginosa as a research model to explore new ways to regulate bacterial infection behavior.
"Pseudomonas aeruginosa is a gram-negative bacterium that is potentially pathogenic to humans, animals and plants, and its clinical isolation rate is high.
Different from the traditional bacterial regulation methods that use chemical inducers to regulate gene expression, the research team used optogenetic regulation and developed a new type of photosensitizer based on the two-component system composed of the GacS protein and GacA protein of Pseudomonas aeruginosa.
"The GacS-GacA two-component system has a key regulatory role in the switch between acute and chronic infection modes of Pseudomonas aeruginosa.
Using the constructed YGS24-GacA light control system, the research team successfully realized the blue light of the bacteria's pathogenic ability to nematodes in the "fatal paralysis" and "slow killing" Caenorhabditis elegans-Pseudomonas aeruginosa pathogenic model Regulation.
"The research and development of YGS24 photosensitive protein expands the tool library of optogenetics and is also the first photosensitive protein developed in Pseudomonas aeruginosa.
In the next step, the research team plans to use this technology, combined with nematode infection experiments, to establish a quantitative relationship model and a pathogenic infection model in a real fluctuating environment through optogenetic methods.
Related paper information: https://doi.