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Few people can imagine that the total number of bacteria in an adult is 100 trillion
Bacteria are the causative agents of many diseases, and they can be infected by contact, insect bites and other methods
On June 2nd, the team of Jin Fan and Huang Shuqiang of the Institute of Synthetic Biology, Shenzhen Academy of Advanced Technology, Chinese Academy of Sciences, published their research results on bacterial infection in the international academic journal ACS Synthetic Biology in the form of a cover article
Yang Shuai said that this research has achieved quantitative and time control of the pathogenicity of bacteria in the host, revealing its local and systemic effects on the health and death of the host
So, how do bacteria infect the host?
According to Jin Fan, bacterial infections often present acute and chronic infection modes
The research team selected a common opportunistic pathogen-Pseudomonas aeruginosa as a research model to explore new ways to regulate bacterial infection behavior
"Pseudomonas aeruginosa is a gram-negative bacterium that is potentially pathogenic to humans, animals and plants, and its clinical isolation rate is high
According to him, different from traditional bacterial regulation methods that use chemical inducers to regulate gene expression, the research team uses optogenetic regulation based on a two-component system composed of Pseudomonas aeruginosa’s GacS protein and GacA protein.
Yang Shuai said that the research team replaced the original GacS protein in the bacteria with YGS24 protein, and constructed the YGS24-GacA light control system to accurately light-control the infection behavior of Pseudomonas aeruginosa
"The research and development of YGS24 photosensitive protein expands the tool library of optogenetics, and is also the first photosensitive protein developed in Pseudomonas aeruginosa
In the next step, the research team plans to use this technology, combined with nematode infection experiments, to establish a quantitative relationship model and a pathogenic infection model in a real fluctuating environment through optogenetic methods
China Youth Daily·China Youth Daily reporter Qiu Chenhui
