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    Home > Biochemistry News > Biotechnology News > How do DNA particles self-assemble?

    How do DNA particles self-assemble?

    • Last Update: 2021-11-14
    • Source: Internet
    • Author: User
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    The video shows a blue particle initially combining with three red particles, satisfying its valence state at room temperature
    .


    When heated, these bonds will be broken, but after cooling, the particle again finds three red partners, which shows that the particle "selected" the number of bonds it formed


    Image credit: Angus McMullen/Department of Physics, New York University

    A group of physicists discovered how DNA molecules self-organize into adhesion patches between particles according to assembly instructions
    .


    Provides a "proof of concept" for an innovative method that can produce materials with clear connectivity between particles


    The research was published in "PNAS"
    .

    Jasna Brujic, a professor and one of the researchers in the Department of Physics at New York University, explained: “We have shown that particles can be programmed to have customized properties and form customized structures
    .


    When constructing buildings, cranes, drills, and hammers must be made by humans.


    Scientists have been looking for ways to self-assemble molecules for a long time and have made breakthroughs in many aspects
    .


    However, it is not yet mature to measure the number of these tiny particles that self-assemble with pre-programmed bonds


    To solve this problem, Brujic and her colleagues, Angus McMullen, postdoctoral fellow in the Department of Physics, and Sascha Hilgenfeldt, professor of mechanical science and engineering at the University of Illinois at Urbana-Champaign, and others conducted a series of experiments to capture and manipulate the behavior of DNA molecules on the surface of particles
    .

    They work at the micrometer level-particles are only 1/25 the size of dust-immersing tiny water droplets in liquid solutions
    .


    Attached to these droplets are "DNA connectors"-molecular tools with "sticky ends" that can be mixed and matched to form a series of structures that researchers want


    Brujic said: "The beauty of this process is that we can program the properties of specific materials to make them elastic or brittle, and even have self-healing ability after breaking, because bonds can be formed and broken, and they are reversible.
    in
    .


    the inventors decided to be placed in a 5 particles, the particles 10, two particle, 20 particles, or any other combination


    The video describing this process can be downloaded from Google Drive 

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