How do milk tea girls survive?

Obesity has been recognized as a global epidemic

Obesity can lead to many related diseases, such as cardiovascular disease, type 2 diabetes, high blood pressure and cancer

There are many reasons for obesity

Poor eating habits are another cause of obesity and are considered to be the main factor

Dietary fiber is a class of non-starch polysaccharides, including some fruits and whole grains

In addition, dietary fiber can absorb bile acids, promote the decline of fat and cholesterol absorption, and reduce the risk of coronary heart disease

Inferred from the evolutionary history of humans, the human gastrointestinal system (gastrointestinal tract, GI) has adapted to the intake of high-fiber foods

Prevention and treatment of obesity often start with diet

Despite all this talk, some people still say: "Exercise and diet, concubines can't do it

Recently, a research team from the University of Salento in Italy published a research paper titled "Biomimetic cellulose-based superabsorbent hydrogels for treating obesity" in the journal "Scientific Reports", reporting for the first time a recognized safety (recognized For safety, the bionic cellulose high-absorption gel method is used to treat obesity

Considering that exercise and dieting require a lot of time and self-control, the researchers are committed to designing a hydrogel that only needs to be taken orally, which is directly conducive to weight control

To this end, the research team developed a cellulose-based superabsorbent hydrogel (cellulose-based superabsorbent hydrogel, CB-SAHs) technology platform

The researchers designed it according to the basic composition and structural characteristics of vegetables, and at the same time gave the hydrogel a unique high water absorption rate, so that it can meet the two key requirements of ease of use and practicality at the same time

Bionic CB-SAH design for weight management

The researchers studied the synthesized CB-SAHs with different elasticity levels and selected the most suitable samples for further development
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Next, the absorption, elasticity and mechanical properties of CB-SAHs were evaluated under simulated gastrointestinal conditions, and the results were consistent with expectations
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CB-SAHs have good adsorption capacity and more extensive degradation
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Finally, the research team also used in vitro organ culture models to evaluate the potential impact of CB-SAHs on the health of intestinal tissues, and tested the safety and effectiveness of these products
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Finally, determine the most suitable safe hydrogel for clinical use
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So, why can CB-SAHs be taken orally before meals to increase satiety and help control weight?

The researchers gave a possible mechanism:

• The swallowed capsule degrades rapidly in the stomach, releasing thousands of CB-SAHs particles
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• Each particle becomes a small gel sheet without heat, the elasticity of which is the same as that of raw vegetables
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• Thousands of gel fragments are mixed with the food ingested, reducing the caloric density of the food
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• When the pH value of gastric juice excretion decreases, CB-SAHs particles will shrink, making it easier to remove from the stomach with food
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• When entering the small intestine, the higher pH rehydrates the particles, increasing their volume and elasticity
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• When the gel fragments reach the colon, similar to the ingested vegetables, they are partially degraded by enzyme activity, release the carried water, and are reabsorbed by the body, and the cellulose material is excreted with the feces
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The underlying mechanism of the action of CB-SAHs

However, CB-SAHs cannot be used as a substitute for vegetables because they do not contain any trace elements
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In this way, an oral, non-systematic weight management tool is created, mainly through the mode of action of mechanobiology
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During the publication of the paper, CB-SAHs products have been clinically studied in the United States and Europe, and have been approved by regulatory authorities
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It shows that hydrogel can be used as an effective auxiliary tool for weight management in the treatment of overweight and obese patients, and can be used in combination with diet and exercise
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It is worth noting that there is no limit to the use time of the hydrogel, because this method has good safety
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In clinical studies, no serious adverse events occurred in the CB-SAH group
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CB-SAHs are still in the clinical research stage
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Its appearance will be the gospel for many obese patients
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Let us look forward to the surprise it will bring to us after its successful development!