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*It is only for medical professionals to read for reference.
What is the clinical significance of the three items of rheumatism? Anti-streptolysin O (ASO), rheumatoid factor (RF), and C-reactive protein (CRP) are common test items in hospitals that combine the "three rheumatism" tests.
Many patients, even non-rheumatologists, believe that the three items of rheumatism are an important basis for the diagnosis and screening of "rheumatism".
How significant are the three items of rheumatism in the diagnosis of "rheumatism"? Let us analyze them one by one.
1CRPCRP is an acute phase response protein secreted by the liver when the body is invaded by microorganisms or tissue injury and inflammation.
In patients with rheumatic diseases, an increase in CRP can be detected in the active stage of the disease, and it can be reduced to normal after the disease is effectively controlled.
Therefore, CRP can be used as an indicator of the activity of rheumatism.
Elevated CRP is a signal released by "inflammation" in the body.
Tissue damage, infection, inflammation, immune inflammation and even tumors are all buttons that stimulate "inflammation" in the body.
Therefore, the detection of CRP alone is not helpful for the diagnosis of rheumatism, and it has certain judgment significance for the evaluation of the diagnosis of rheumatism.
2RFRF mainly exists in the serum and synovial fluid of patients with rheumatoid arthritis.
It is an autoantibody against deformed IgG.
IgM type is considered to be the main type of rheumatoid factor.
Popular science articles about "rheumatoid factor and rheumatoid arthritis" can be seen everywhere-although rheumatoid factor is named after rheumatoid arthritis, it can appear in other diseases, such as Sjogren’s syndrome, chronic hepatitis B infection, blood disease Wait.
RF can also be detected in 5% of healthy people.
Although RF is positive, it is not necessarily rheumatoid arthritis.
However, for high-titer RF (≥3 times the upper limit of normal), it is still necessary to carefully investigate the possibility of rheumatic diseases in combination with the patient's medical history and physical examination.
3ASOASO is after the human body is infected with group A hemolytic streptococcus, the human body will appear corresponding antibodies to correspond to the hemolysin O produced by it, that is, "anti-O".
The normal value is generally below 200 units.
If it is higher than 200 units, it means that you have had a hemolytic streptococcal infection recently.
Streptococcal infection generally indicates rheumatic fever, but the current incidence of rheumatic fever is very low.
Most of the clinically elevated ASOs are post-streptococcal infections.
If there is no clear migratory pain in the large joints (shoulder, knee, ankle, etc.
), drug treatment is generally not required.
It is difficult to diagnose a rheumatism through the three items of rheumatism, but as mentioned above, high titers of RF and CRP should be vigilant against the possibility of rheumatism.
The correct approach is to take the rheumatism test sheet, go to the rheumatology department, listen to the analysis and opinions of rheumatologists, and further improve the specific examination of rheumatism-the detection of autoantibodies.
Determine if there is rheumatism.
What is the clinical significance of the three items of rheumatism? Anti-streptolysin O (ASO), rheumatoid factor (RF), and C-reactive protein (CRP) are common test items in hospitals that combine the "three rheumatism" tests.
Many patients, even non-rheumatologists, believe that the three items of rheumatism are an important basis for the diagnosis and screening of "rheumatism".
How significant are the three items of rheumatism in the diagnosis of "rheumatism"? Let us analyze them one by one.
1CRPCRP is an acute phase response protein secreted by the liver when the body is invaded by microorganisms or tissue injury and inflammation.
In patients with rheumatic diseases, an increase in CRP can be detected in the active stage of the disease, and it can be reduced to normal after the disease is effectively controlled.
Therefore, CRP can be used as an indicator of the activity of rheumatism.
Elevated CRP is a signal released by "inflammation" in the body.
Tissue damage, infection, inflammation, immune inflammation and even tumors are all buttons that stimulate "inflammation" in the body.
Therefore, the detection of CRP alone is not helpful for the diagnosis of rheumatism, and it has certain judgment significance for the evaluation of the diagnosis of rheumatism.
2RFRF mainly exists in the serum and synovial fluid of patients with rheumatoid arthritis.
It is an autoantibody against deformed IgG.
IgM type is considered to be the main type of rheumatoid factor.
Popular science articles about "rheumatoid factor and rheumatoid arthritis" can be seen everywhere-although rheumatoid factor is named after rheumatoid arthritis, it can appear in other diseases, such as Sjogren’s syndrome, chronic hepatitis B infection, blood disease Wait.
RF can also be detected in 5% of healthy people.
Although RF is positive, it is not necessarily rheumatoid arthritis.
However, for high-titer RF (≥3 times the upper limit of normal), it is still necessary to carefully investigate the possibility of rheumatic diseases in combination with the patient's medical history and physical examination.
3ASOASO is after the human body is infected with group A hemolytic streptococcus, the human body will appear corresponding antibodies to correspond to the hemolysin O produced by it, that is, "anti-O".
The normal value is generally below 200 units.
If it is higher than 200 units, it means that you have had a hemolytic streptococcal infection recently.
Streptococcal infection generally indicates rheumatic fever, but the current incidence of rheumatic fever is very low.
Most of the clinically elevated ASOs are post-streptococcal infections.
If there is no clear migratory pain in the large joints (shoulder, knee, ankle, etc.
), drug treatment is generally not required.
It is difficult to diagnose a rheumatism through the three items of rheumatism, but as mentioned above, high titers of RF and CRP should be vigilant against the possibility of rheumatism.
The correct approach is to take the rheumatism test sheet, go to the rheumatology department, listen to the analysis and opinions of rheumatologists, and further improve the specific examination of rheumatism-the detection of autoantibodies.
Determine if there is rheumatism.
