How does plasticizer affect reproductive function? Causes too many DNA fractures

WASHINGTON, Jan. 11 (Xinhua Liu Haiying) U.S. researchers in the Public Library of Science, Genetics, published a study on the 9th, a commonly used plasticizer - phthalates (DEHP) in the online worm reproductive process caused excessive DNA fractures, and interfere with the operation of repair systems, resulting in egg formation and early embryo development defects. The discovery of this new mechanism is important for understanding the impact of DEHP on human reproductive health.
DEHP is currently the most widely used plasticizer, with a total global production of up to 4 million tons per year, and people will be exposed to it through toys, clothing, food packaging, medical devices, personal care products and other products. Numerous studies have shown that exposure to DEHP can cause fertility problems for both men and women, but so far scientists have been unable to confirm how the chemical works harmfully.
, researchers at Harvard Medical School and the New York State Department of Health studied the effects of DEHP exposure on the reproductive function of beautiful cryptobacteriasis. They found that DEHP causes excessive double-stranded DNA fractures during in-line worm cell subtracting and interferes with the functioning of repair systems, making these fractures impossible to repair properly, ultimately affecting chromosomal morphology, resulting in incorrect numbers of chromosomes in eggs and decreased embryo viability.
analysis showed that these worms were affected only by low levels of DEHP exposure and metabolism (equivalent to the DEHP levels detected in urine samples from the general population). This suggests that even a small amount of DEHP can destroy the subtracting of cells.
is a common pattern organism in the study of human genetics and biology. The researchers say their new study provides new insights into how DEHP levels in the environment can damage the animal reproductive system and is important to better understand how DEHP affects human reproductive health. The study also warns that to focus on DEHP contamination, it is necessary to reduce the use of DEHP or to find safer alternatives to minimize the risk of exposure to the chemical.