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Scientists at the University of East Anglia have published a paper in the journal Molecular Oncology describing how prostate cancer may begin to develop
.
"Up to 80% of prostate cancer cases present with multifocal independent tumor lesions, which leads to the concept of a field effect in the normal prostate, which leads to the development of
cancer.
"With single nucleotide variants and small insertions and deletions (indels), BPH was significantly higher in prostate cancer patients than in non-prostate cancer patients
.
This is the most common cancer in men
"Prostate cancer is the most common cancer in men, with a man dying every 45 minutes in the UK," said lead researcher Dr Daniel Brewer from the Norwich School of Medicine at the University of East Anglia.
The samples Brewer's team studied included tissues from cancer and other parts of the prostate that looked normal
under the microscope.
"This generates a lot of data, and by applying a lot of computer power, we can identify the differences that occur in the DNA, allowing us to understand how cancer grows," he explains
.
The "normal" prostate cells in men with prostate cancer appear to provide a favorable environment
for the development and growth of prostate cancer cells.
"In other words, the entire prostate is driven by an unknown biological process and is ready for prostate cancer," he explains
.
The new study shows for the first time how normal cells in the prostate promote the growth and spread of
prostate cancer.
The researchers found that normal prostate cells in men with prostate cancer have specific genetic changes that make them look like a rich compost that provides the perfect environment
for prostate cancer cells to grow and develop.