How effective is the third dose of the new crown vaccine?

▎A number of studies on the long-term protective efficacy of vaccines edited by WuXi AppTec's content team show that over time, the effectiveness of the new crown vaccine in preventing disease infection has decreased
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Whether a third dose of booster vaccine is needed, and when to do booster vaccination has also become a topic of public concern
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A number of studies have shown that vaccination with booster vaccines can significantly increase the level of neutralizing antibodies in the human body
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Real-world data from Israel also shows the protective effect of vaccination in the elderly
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Today, Pfizer and BioNTech jointly published the results of a phase 3 clinical trial of new crown enhanced vaccination.
Compared with placebo, the protective effect of enhanced vaccination was 95.
6%
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The press release states that this is the first randomized double-blind, placebo-controlled Phase 3 clinical trial of enhanced vaccination
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It provides more scientific basis for guiding enhanced vaccination
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This clinical trial enrolled more than 10,000 adults over 16 years old, their median age was 53 years old, 55.
5% of participants were 16-55 years old, and 23.
3% of participants were seniors over 65 years old
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They have previously received two doses of Pfizer/BioNTech's new crown vaccine
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These volunteers were randomly given a booster vaccine or a placebo
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The median time between the second dose of vaccine and the booster vaccine is about 11 months
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At least 7 days after receiving the booster vaccine or placebo, the researchers detected cases of COVID-19 with symptoms
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At a median follow-up time of 2.
5 months, there were 5 symptomatic COVID-19 patients in the booster vaccination group, compared to 109 in the placebo group
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The relative vaccine efficacy calculated based on these data was 95.
6% (95% CI: 89.
3, 98.
6)
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In terms of safety, the characteristics of adverse events were consistent with previous clinical safety, and no new safety signals were found
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Image source: 123RF Pfizer and BioNTech plan to submit detailed data to peer-reviewed scientific journals, and will share these data with regulatory agencies around the world as soon as possible
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The new crown vaccine is one of the safest and most effective protective measures to prevent COVID-19, especially hospitalization and death caused by severe COVID-19
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Whether it is necessary to vaccinate the booster vaccine and when to vaccinate the booster vaccine needs to be answered based on scientific analysis based on various data such as laboratory data and clinical trial data
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At present, a number of new crown vaccine development companies have released experimental data to enhance vaccination to increase the level of human neutralizing antibodies
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We look forward to more scientific evidence that can effectively guide the planning and implementation of enhanced vaccination, help control the new crown epidemic, and protect public health
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Reference: [1] PFIZER AND BIONTECH ANNOUNCE PHASE 3 TRIAL DATA SHOWING HIGH EFFICACY OF A BOOSTER DOSE OF THEIR COVID-19 VACCINE.
Retrieved October 21, 2021, from https:// /press-release-detail/pfizer-and-biontech-announce-phase-3-trial-data-showing Disclaimer: WuXi AppTec's content team focuses on introducing global biomedical health research progress
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This article is for the purpose of information exchange only.
The opinions expressed in the article do not represent the position of WuXi AppTec, nor does it mean that WuXi AppTec supports or opposes the views in the article
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This article is not a treatment recommendation either
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If you need guidance on treatment plans, please go to a regular hospital for treatment
.