How Equal Charges in Enzymes Control Biochemical Reactions

The team looked at a well-known enzyme that has been studied extensively and is a textbook example of enzymatic catalysis

Professor Kai Tittmann's team at the Göttingen Center for Molecular Biosciences (GZMB) has now succeeded for the first time using protein crystallography to obtain structural snapshots of substrates shortly before chemical reactions

"We believe that these newly described principles of enzymatic catalysis will aid in the development of new chemical catalysts," Tittmann said

Faculty of Scientists Research Center for Molecular Biosciences (GZMB), Biology and Psychology in Göttingen, and Faculty of Chemistry at the University of Göttingen, and the European Molecular Biology Laboratory (EMBL) at the Max Planck Institute for Multidisciplinary Science ) Hamburg and the University of Toronto

Journal Reference :

1. Sören Rindfleisch, Matthias Krull, Jon Uranga, Tobias Schmidt, Fabian Rabe von Pappenheim, Laura Liliana Kirck, Angeliki Balouri, Thomas Schneider, Ashwin Chari, Ronald Kluger, Gleb Bourenkov, Ulf Diederichsen, Ricardo A.