echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Endocrine System > How much do you know about soy isoflavones, a non-drug option to combat "menopausal hot flashes" on World Menopause Care Day?

    How much do you know about soy isoflavones, a non-drug option to combat "menopausal hot flashes" on World Menopause Care Day?

    • Last Update: 2021-11-05
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    This article is published under the authorization of the author, please do not reprint without permission
    .

     Guide: I am troubled by menopausal hot flashes, but I am worried about the side effects of estrogen.
    What other methods can be improved except for drugs? The author introduces Professor Mou Lining, chief nurse/professor, master tutor, secretary general of Jinan Nutrition Society, fitness coach (National Vocational Qualification Certificate Level 5), chairman of Jinan Nursing Society Outpatient and Emergency Special Committee, Jinan Nutrition Society Sports and Nutrition Specialty The chairman of the committee, the first health ambassador of Shandong Province, and the deputy director of the outpatient department of Jinan Central Hospital affiliated to Shandong University, the World Menopausal Medicine Association will set October 18th every year as "World Menopause Care Day"
    .

    Speaking of menopause, menopausal hot flashes cannot be avoided.
    The first time I saw the onset of menopausal hot flashes was a very accidental opportunity-an older sister who was talking suddenly flushed, with fine sweat on her face and neck.
    , I quickly asked her if her heart is uncomfortable, she said embarrassingly: "It doesn’t matter, I have menopausal hot flashes, I have 10 episodes a day, and sometimes it becomes more serious when I am anxious
    .

    I don’t want to take medicine, and there is nothing more.
    The good way, I have to stick to it
    .

    " How many years later, this scene of witnessing the "sauna" state up close is still vivid
    .

    Does every menopausal woman experience such severe discomforts caused by menopausal hot flashes? 1.
    A "hurdle" that women have to go through in their lives-menopausal syndrome, is there any other way besides taking medicine? Menopausal syndrome is a series of symptoms caused by a drop in estrogen levels
    .

    In menopausal women, when hot flashes occur, in front of others, a thin layer of sweat on the face, neck and even multiple parts of the face, neck and even multiple parts is very embarrassing; after others, different degrees of heart palpitations, insomnia, fatigue, and depression and so on
    .

    The severity of menopausal hot flashes varies from person to person
    .

    Among women in the transitional period of menopause, 60% to 80% of women will have hot flashes.
    The onset of hot flashes can last from a few seconds to a few minutes.
    About one-third of women cannot tolerate the symptoms of menopause and choose to seek medical treatment.

    .

    Some people are tired, helpless, and depressed due to symptoms.
    Some people are unwilling to receive medication and just want to relieve hot flashes
    .

    Therefore, this sad and visible state of "sauna" hot flashes can be improved by medical nutrition treatment methods other than drugs? In this paper, in conjunction with the following terms of guidelines, literature, patents, etc.
    , make relevant nutrition recommendations
    .

    The principle of menopausal hot flashes: The occurrence of hot flashes is related to the narrowing of the thermoneutral zone of central body temperature regulation
    .

    Normally, there are two limits of the body temperature regulation center.
    One upper limit is the limit of heat dissipation, that is, when the central body temperature exceeds the upper limit, the peripheral blood vessels relax to dissipate heat; when the central body temperature is lower than the lower limit, the blood vessels contract and shiver to produce heat to maintain body temperature.
    Keep it in the normal range
    .

    The narrowing of the thermal neutral zone is due to the withdrawal of estrogen on the one hand, and more importantly the enhancement of central sympathetic activity, that is, norepinephrine, serotonin, dopamine and other neurotransmitters play an important role in central regulation and promote peripheral The body temperature rises, increasing the radiation heat and evaporation heat, so that the core body temperature returns to the normal range
    .

    Classification of the severity of menopausal symptoms: According to the "Guidelines for Menopausal Women's Health Care (2015)", the modified Kupperman score is used as the standard: score ≤ 6 is considered normal, 6 <score ≤ 15 is considered mild, 16 <score ≤ 30 is considered moderate Degree, score>30 is classified as severe
    .

    2.
    Soy isoflavones-the "variable" regulation of estrogen.
    Soy isoflavones are generally extracted from soybean seeds, and the content in cotyledons and hypocotyls is relatively high, accounting for about 80% to 90%, and the content in the seed coat Rarely
    .

    Its bisphenol structure is very similar to the estrogen structure of the human body, so it has an estrogen-like effect
    .

    When the human body consumes soy products, the concentration of isoflavones in the blood will change due to the concentration of ingested isoflavones, and they will eventually pass through the body and be excreted from the body
    .

    The biggest difference from ordinary estrogen is that soy isoflavones are a "variable" regulation of estrogen
    .

    In humans with low estrogen levels, soy isoflavones act as an "agonist" of estrogen, which binds to the estrogen receptor (ER) and exerts an estrogen-like effect
    .

    For people with high estrogen levels, soy isoflavones can become an "antagonist" that inhibits the secretion of estrogen
    .

    In layman's terms, an "antagonist" is a "dominant effect"
    .

    The estrogen in the body must bind to the receptor to exert its effect.
    When the level of estrogen in the body is relatively high, soy isoflavones bind to the receptor of estrogen, occupying the "seat" (occupying receptor binding) belonging to estrogen.
    As a result, there are fewer binding points for estrogen, which is equivalent to playing an anti-estrogen effect
    .

    3.
    Evidence-based basis for soy isoflavones in the treatment of "menopausal syndrome" First of all, any medical nutrition treatment cannot replace drug treatment
    .

    Those with severe symptoms or those seeking medical treatment are advised to follow the doctor’s instructions for systemic treatment
    .

    Soy isoflavones can significantly improve menopausal symptoms such as hot flashes
    .

    The meta-analysis of 19 randomized controlled trials showed that after menopausal women supplemented with soybean isoflavones daily from soybeans, soybean extracts, and genistein for one week, the frequency of hot flashes can be reduced
    .

    However, soy isoflavones have no effect on alleviating the vascular symptoms of menopause, nor can it improve the effect of exogenous estrogen on the birth canal of postmenopausal women
    .

    A study in the Nutrition Department of the First Medical Center of the PLA General Hospital observed the effect of soybean isoflavones on female hormone levels.
    Oral 2 tablets/time, 2 times/d (each soybean isoflavones contains 15mg of isoflavones, a total of 60mg/d, After 6 months of intervention, compared with the control group (CG) group, the level of estradiol (E2) in the soy isoflavone group (SI) group increased, and the level of luteinizing hormone (LH) decreased, suggesting the possibility of soy isoflavones by regulation of the endocrine system gonadal axis thereby delaying the loss of ovarian secretory function
    .

    efficacy of soy isoflavone diet is to relieve menopausal symptoms
    .

    Patent CN109511764A disclosed in the chocolate making process, adding soy isoflavones, for improving the menopause syndrome
    .

    Pat.
    CN106509890A combines soybean isoflavones, Antarctic krill oil, turmeric butter and other ingredients into soft capsule composition products, which has a significant effect on relieving female menopausal syndrome
    .
    And
    patents CN104940241A and CN103070940A use soybean isoflavones and other plant active ingredients, respectively It is made into health products to prevent and treat female menopausal syndrome
    .

    Soy isoflavones are a kind of polyphenolic nutrients and also have antioxidant effects
    .
    They
    can improve postmenopausal osteoporosis.
    Soy isoflavones can reduce LDL-C, Raise HDL-C, lower cholesterol and prevent atherosclerotic coronary heart stroke and high blood pressure, and have a protective effect on the cardiovascular system
    .

    The meta-analysis in the "Chinese Diabetes Medical Nutrition Treatment Guidelines (2013)" shows that the use of soybeans is different When flavonoids intervene in diabetes, although there is no significant reduction in blood sugar, they can improve insulin resistance and have a certain regulatory effect on glucose metabolism
    .

    4.
    What should be the intake of soy isoflavones during perimenopausal intervention? 1.
    For the dosage of soy isoflavones for intervention in perimenopausal women, the standards established by countries are different.
    According to the "Chinese Residents' Dietary Nutrient Reference Intake 2013 Edition", the specific recommended value (SPL) of soy isoflavones is 55mg/d, The tolerable maximum intake (UL) is 120mg/d
    .

    According to the data of the second edition of the Chinese Nutrition Science, the average intake of soy isoflavones in the daily diet of Chinese residents is 12-25mg/d.
    If the symptoms of menopause are improved, there is still a lack of 30mg per day.
    If there is no special long-term supplement (3- 6 months), the daily diet should not worry about excessive intake
    .

    Are all beans rich in isoflavones? The Chinese food composition table and the US Department of Agriculture database show that the content of isoflavones in soybeans is much higher than that of other legumes, with 120-154mg per 100g (depending on the soybean sample), while the content of other legumes is less than 3mg.
    Some are less than 1mg
    .

    This proves that soybeans and their products are high-quality sources of isoflavones
    .

    Soy isoflavone content of soybeans and their products: 100g soybeans contains 128mg soybean isoflavones, 200g tofu contains 55mg, and 100g soy milk contains 10mg
    .

    Calculated based on the 60mg/d intake of soy isoflavones, you need 50g soybeans, 200g tofu, and 600g soy milk
    .

    Of course, in order to facilitate long-term adherence, you can take 250g of soybeans, add 250ml of water to soak softly, and cover
    .

    Place it in a rice cooker and press for 30 minutes to completely soften
    .

    In order to improve the taste, you can also add red beans and red dates to make soy sauce.
    Take 50-70g of the above-mentioned soy isoflavone foods such as soy sauce every day (2 scoops per day)
    .

    The picture is original by the author 2.
    The dosage should be adjusted according to the severity of menopausal hot flashes and the severity of physiological and neurological symptoms.
    Those with mild symptoms, that is, those with hot flashes less than 6 times per day, can take a certain amount of soy isoflavones in their diet every day For foods such as soybeans, tofu, and soy milk, learn to be familiar with the conversion of the amount of isoflavones in the food intake to ensure a certain amount of isoflavones
    .

    The symptoms improved or disappeared after a few days
    .

    For severe symptoms, give soybean isoflavone tablets, which are health care products.
    Please follow the instructions for dosage and usage
    .

    To evaluate the curative effect, the Kupperman score sheet can be evaluated before and after use.
    If necessary, estradiol, luteinizing hormone, etc.
    can be tested for comparison before and after medical treatment
    .

    The time to onset is also based on individual differences, and those with severe deficiency will only have an effect around 1 month
    .

    5.
    Can soy isoflavones be supplemented with combined mammary gland hyperplasia? If you have breast hyperplasia, uterine fibroids, or even breast cancer, will eating soy isoflavones aggravate the condition? The answer is: because soy isoflavones are only similar in structure to estrogen, they can bind to estrogen receptors and produce a weaker estrogen effect.
    Therefore, for the symptoms of hot flashes, you can take appropriate amounts of soy isoflavones within a safe dose to alleviate the symptoms.

    .

    References: 1.
    Mi Mantian.
    Intake and recommended amount of soybean isoflavones [C].
    Compilation of the Second Dietary Nutrient Reference Intake Symposium of Chinese Nutrition Society, 2011:124-138.
    2.
    Wen Shaoxia, Yan Hongli.
    Soybean Isoflavones Observation on the efficacy of flavonoids in the treatment of 50 cases of perimenopausal menopausal syndrome.
    Qilu Nursing Journal, 2016, 22(11): 124-125.
    3.
    Liu Lu, Lu Chunjian, Zhang Xinsheng, etc.
    Intervention of soybean isoflavones on perimenopausal women’s syndrome and sex hormone levels Research on the impact of food and nutrition in China.
    2020,26(11):60-63.

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.