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    Home > Biochemistry News > Biotechnology News > How omega-3 fatty acids reduce atherosclerosis

    How omega-3 fatty acids reduce atherosclerosis

    • Last Update: 2021-12-27
    • Source: Internet
    • Author: User
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    A receptor activated by a substance formed from omega-3 fatty acids plays a vital role in preventing vascular inflammation and reducing atherosclerosis
    This discovery could pave the way for new strategies for using omega-3 fatty acids to treat and prevent cardiovascular diseases

    Cardiovascular disease is the most common cause of death in the world and a serious public health problem
    Atherosclerosis is related to chronic inflammation in blood vessels

    Inflammation a is usually controlled by stop signals called resolveins, which shut down inflammation and stimulate tissue healing and repair through a process called inflammation resolution

    Lysin is formed from omega-3 fatty acids and binds to and activates a receptor called GPR32

    Hildur Arnardottir, the first author of the study and an assistant professor in Solna’s Department of Medicine, said: “We found that this receptor is dysregulated in atherosclerosis, indicating the body’s natural healing process.

    " Karolinska Institute

    "This discovery can pave the way for new strategies for the treatment and prevention of atherosclerosis, for example, by preventing inflammation of the blood vessels while opening the body's healing process with the help of omega-3 fatty acids


    This new study shows that signals sent through receptors can effectively prevent inflammation of atherosclerotic blood vessels and promote healing
    Researchers studied atherosclerotic plaques and created a new experimental model that has overexpressed GPR32 receptors

    GPR32 receptors fight atherosclerosis and vascular inflammation, and lysin that activates GPR32 enhances this effect

    Magnus B?ck, the last author of the study, said: "We will now study the mechanisms behind the failure of vascular inflammation management and how to use omega-3 mediated stop signals to treat atherosclerosis

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