How terrible is Delta Plus: more infectious and easier to bind to lung cells

It is only for medical professionals to read for reference.
It is better than planting the same pit twice! An upgraded version of the Delta mutant has appeared.
It also originated in India and spread in 13 countries including the United States and the United Kingdom.
Scientists are trying to figure out the news about it
.

The pathogenesis of the "same" difference between Delta Plus and Delta strains: K417N mutation in GISAID, this new mutant strain is called Delta Plus, there are two types of AY.
1 and AY.
2, and the Delta mutant strain ( B.
1.
617.
2) placed in the same VOC classification
.

The global distribution of Delta and Delta Plus AY.
1 is relatively popular globally, and it has spread in the United States, Portugal, Britain, France, Switzerland, Belgium, Denmark, Poland, Romania, Nepal, Japan, and Russia; and AY .
2 Mainly spread in the United States and Turkey
.

The difference between Delta Plus and the Delta mutant is that it has an additional mutation at the K417N site
.

K417N is located in the S protein on the surface of the new coronavirus.
It is not the first time that it has been found to be mutated.
It was first discovered in the Beta mutant strain in South Africa, where this mutation was also found
.

The name of the variant strain was the first national variant site found Alpha variant (B.
1.
1.
7) UK ∆H69, ∆V70, ∆Y144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118HBeta variant (B.
1.
351) South Africa L18F, D80A, D215G, ∆L242, ∆A243, ∆L244, R246I, K417N, E484K, N501Y, D614G, A701VGamma variants (P.
1) Brazil L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y , D614G, H655Y, T1027IDelta variants (B.
1.
617.
2) India T19R, G142D, ∆157-158, L452R, T478K, D614G, P681R, D950NDelta Plus variants (B.
1.
617.
2.
1) India T19R, G142D, ∆ 157-158, L452R, T478K, D614G, P681R, D950N, K417N where is the mutation site of several popular variants of Delta Plus upgrade: transmission and binding power is stronger The virus is constantly mutating, and the mutation may make the virus Some changes have occurred, such as being better at infecting cells, easier to spread, or better at replicating
.

The Ministry of Health of India designated Delta Plus as a worrisome variant (VOC) on June 22, because they found that this strain is more transmissible and binds to lung cell receptors.
And there is the potential for immune escape
.

GISAID has classified Delta Plus as a VOC along with the Delta variant.
However, regarding whether Delta Plus meets the criteria for naming a VOC, Ravindra Gupta, an immunologist and infectious disease expert at the University of Cambridge, said: "India is cautiously calling it a VOC.
, Not based on any hard data
.

“India’s New Coronavirus Gene Consortium (INSACOG) scientific advisory group leader and virologist Shahid Jameel believes: “The new mutation will not make Delta Plus less transmissible than the Delta mutant strain, or will not reduce the virus’s ability to evade immune response.
Ability
.

"Therefore, he believes that there is nothing wrong with naming Delta Plus as VOC
.

Studies have shown that mutations at the K417N site can help Beta mutants to evade antibodies.
This precedent means that Delta Plus may be easier to evade antibodies than Delta mutants.
The effect of a vaccine on Delta Plus may be compromised
.

It is reassuring that the preliminary results of existing studies show that some of the antibodies produced by the vaccinated individuals have a neutralizing effect on Delta Plus
.

In addition to worrying emotions, there are also experts Be relatively optimistic or keep a wait-and-see attitude
.

At present, about half of the Delta Plus cases in the UK occur in people who have not been vaccinated, but none of the Delta Plus infected patients have died
.

Therefore, some scientists speculate that the K417N mutation , May weaken Delta Plus
.

Some people think that it is too early to conclude that there is a problem with Delta Plus .
Because India, Nepal and other countries where Delta Plus may be popular, their sequencing technology is limited and there is not enough sequence yet.
, Can determine the infectiousness, lethality and immune escape of Delta Plus in the population
.

Recent developments in various countries: the students who have been beaten are getting better, and the more they gather, the more infection.
According to CNN, according to the data of the British Ministry of Public Health, as of June On the 25th, 83 cases of Delta Plus were found in the United States and 41 cases were reported in the United Kingdom
.

On June 25, an 80-year-old Delta Plus female infected with a previous disease in India was confirmed dead
.

INSACOG announced on June 28 that India has detected AY.
1 variants in 56 samples
.

The announcement stated that the current growth rate of AY.
1 infection cases is not faster than that of the Delta variant, but INSACOG is paying close attention to the situation
.

As Maharashtra was hit hard by the second wave of new coronaviruses, the Indian people are particularly worried about Delta Plus, and now the state has re-implemented the blockade
.

"Vaccines sometimes don't work
.

" said Bruce Aylward, a senior consultant at WHO
.

Out of caution, WHO recommends that vaccinated people continue to wear masks, not only to continue to ensure safety, but also to prevent people from becoming part of the virus transmission chain
.

Although many countries have taken preventive measures against Delta mutant strains and Delta Plus, there are still many large-scale activities that are being carried out in various places or are about to take place in the near future
.
The problem of increased risk of infection faced by many people still exists .

Since the start of the European Cup on June 11, St.
Petersburg, Russia, as one of the host cities of the European Cup, has welcomed a large number of fans to watch the game
.

According to the BBC report, during the football game, the number of cases of new crown infection in Russia increased sharply.
Soon after the game started, the number of hospitalized patients with new crown infection in Moscow increased by 70% compared with last week
.

90% of the infections were caused by the Delta mutant strain, and one case of Delta Plus infection was found on June 29
.

But Russia still has not implemented a nationwide lockdown, and the situation of vaccination is very poor
.

According to a report by ITAR-Tass, facing the quarter-finals to be held in St.
Petersburg on July 2, Russia’s World Cup Organizing Committee’s press office announced: “Safety measures will be maintained, including mandatory masks and social distancing”, but it still Allow 50% of the capacity of the stadium to enter the stadium to watch the game
.

Recently, according to a report by Al Jazeera on July 4, the number of deaths from the new crown virus in Russia hit a record high for five consecutive days
.

A 21-year-old student in Moscow waiting for the vaccine to be vaccinated told reporters: "I want to get an injection and feel safe
.

" On July 2nd in Moscow, medical staff in protective clothing used a stretcher to transport people infected with the new crown virus (Source: Reuters) Agency) There is only half a month left before the Tokyo Olympics, which will start on July 23, but Tokyo’s opinion polls show that most people hope to cancel or postpone the games
.

Japanese Prime Minister Yoshihide Suga said that if necessary, he would not hesitate to ban spectators from watching the game
.

However, whether the Tokyo Olympics can proceed smoothly is really worrying
.

According to the People's Daily Overseas Network, on July 6, two staff members of the Tokyo Olympic Village were diagnosed with the new crown.
The reason turned out to be that they had a meal with two close contacts of the virus
.

Even more frightening is that since the implementation of the third version of infection prevention measures on the 1st, 12 staff members of the Tokyo Olympics have been diagnosed
.

The safety of tens of thousands of Olympic athletes also worries people from all over the world
.

According to Xinhua News Agency, a nine-member Olympic delegation from Uganda arrived in Tokyo on June 19.
One of them was tested positive for the new crown when entering the country, and another was diagnosed with the infection on the 23rd.
One of the two was infected with Delta.
Mutant strain, the delegation has been quarantined by all members
.

We don’t know what the future will be like, but the lessons of the Delta variant pandemic remind us that the safest measure is still to take precautions—avoid gathering and vaccination.

.

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06.
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.
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.
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[6]Russia reports case of COVID-19's Delta Plus — official-Society & Culture-TASS[7]https:// measures in St.
Petersburg to remain unchanged for 2020 Euro quarterfinal-Sport-TASS[9]https:// // 2 staff members of the Tokyo Olympic Village were diagnosed with close contacts Dining at the same table-Original-Overseas Network [12] Baidu Security Verification