How to improve the distillation and purification efficiency of the rotary evaporator?

Rotary evaporator, also known as rotary evaporator, is mainly used for concentration, crystallization, drying, separation and solvent recovery
in pharmaceutical, chemical and biopharmaceutical industries.

Its principle is that under vacuum conditions, constant temperature heating, so that the rotating bottle rotates at a constant speed, and the material forms a large area film on the bottle wall and evaporates
.

The solvent vapor is cooled by a glass condenser and recycled in a collection bottle, greatly improving the evaporation efficiency
.

It is especially suitable for the concentration and purification
of biological products that are easily decomposed and denatured at high temperatures.

The distillation efficiency of the rotary evaporation instrument in the laboratory is a very important performance, and the distillation efficiency determines the experimental efficiency on the one hand, and on the other hand, it also reflects the quality of a product
.

The distillation efficiency of the laboratory rotary evaporator determines the number of samples that can be distilled per day, and one obvious reason is that the higher the distillation efficiency of the same solvent, the more
samples are distilled.

So how to improve the distillation and purification efficiency of the rotary evaporator and what are the reasons that affect the work of the rotary evaporator, let's take a look at it! 1.
The temperature of the cooling medium is generally recommended to maintain a temperature difference of about 40 ° C with the temperature of the heating pot to ensure the distillation efficiency and the cooling medium in order to quickly condense the hot steam, thereby reducing the influence of the steam on
the system vacuum.

2.
The temperature of the heating pot laboratory rotary evaporator heating pot temperature is higher, the faster the distillation effect of the solvent, but considering the safety of operation and the heat sensitivity of the target ingredient, the commonly used temperature is 60 ° C and then more than 80 ° C, but the silicone oil medium is difficult to clean, generally we recommend that customers reduce the vacuum value to achieve faster distillation efficiency
.

3.
In general, the lower the vacuum pump limit, the lower
the vacuum value of the system.

Therefore, when distilling, it is necessary to set a reasonable vacuum value through the vacuum controller to ensure the distillation efficiency and avoid bumping
.

The ultimate vacuum of the circulating water pump is about 0.
098mpa, and the ultimate vacuum of the diaphragm vacuum pump can reach 1.
5 mbar, but if the budget allows the vacuum controller to be installed, it can control the system vacuum value
required for distillation.

In summary, the reasons for the operation of the rotary evaporator: the vacuum value of the system The temperature of the heating pot The speed of the evaporation bottle The temperature of the cooling medium