How to solve the problem of antibiotic abuse?

Antibiotics can be said to be the standing medicine of every family.

At present, the abuse of antibiotics has become one of the problems that threaten global public health.

Recently, a research team from New York University in the United States published a research report titled Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance in Science.

DOI: 10.

Studies have pointed out that at present, one way to solve the problem of antibiotic resistance is to break the defense system that protects pathogens from the interference of antibiotics.

Since almost all pathogens produce H2S through homologous enzymes such as mammalian cystatin lyase (CSE) and cystatin b synthetase (CBS), the researchers first verified which enzyme is the main source of H2S

As a result, the researchers used bCSE as the target, after structure-based computer virtual screening, selected 3.

The researchers used the Staphylococcus aureus sepsis model and the Gram-negative Pseudomonas aeruginosa lung infection model to further verify the three compounds in vivo and in vitro.

The chemical structure and experimental results of the selected bCSE inhibitors

So far, no targeted drug for retaining bacteria has been approved by the U.