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    Home > Active Ingredient News > Drugs Articles > How to test the dissolution of small molecules in rubber gasket?

    How to test the dissolution of small molecules in rubber gasket?

    • Last Update: 2018-01-04
    • Source: Internet
    • Author: User
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    Abstract: rubber gasket is a commonly used sealing device For food or medical rubber gasket, the amount of small molecules dissolved in it has an important impact on the safety of food and medicine In this paper, Labthink Languang ert-01 evaporation residue constant weight instrument is used to test the content of small molecular substances in the food grade rubber gasket produced by an enterprise Through the simple description of the test principle, equipment parameters, application scope, test process, etc., a method to detect the content of small molecular substances is provided for the enterprise Key words: rubber gasket, small molecule substance, evaporation residue, evaporation residue weight gauge, nonvolatile substance, total migration 1 Significance rubber gasket is a common sealing gasket with good temperature resistance, aging resistance, oil resistance, acid and alkali resistance, which is commonly used in medicine, electronics, chemical industry, food and other industries The main rubber gasket includes silica gel gasket, butyl rubber gasket, fluororubber gasket, EPDM rubber gasket, etc in order to ensure the good performance of these rubber gaskets, some small molecular substances will inevitably be introduced in the production process, and these substances will move out slowly When the rubber gasket contacts with food, medicine, etc., especially if it contains liquid, grease or needs With high-temperature processed food and drug, these substances are likely to migrate to food and drug, causing food and drug pollution and affecting the health of consumers Therefore, for the rubber gasket for food or medicine, on the basis of ensuring the good performance of the gasket, the content of small molecular substances should be controlled as much as possible to ensure the safety of the food and medicine it contacts Fig 1 various types of rubber gasket 2 In this paper, the food grade rubber gasket produced by an enterprise is used as the test sample 3 The test is based on GB / T 5009.64-2003 analysis method of hygienic standard for rubber gasket (ring) for food According to the test process of evaporation residue in the standard, the content of nonvolatile small molecules (total migration) that can be migrated out of the sample is tested 4 In this paper, ert-01 evaporation residue constant weight instrument is used to test the evaporation residue of rubber gasket samples, which is independently developed and produced by Jinan Languang Electromechanical Technology Co., Ltd Fig 2 test principle of ert-01 evaporation residue constant weight instrument 4.1 According to the actual application of rubber gasket and the type of food contacted, select the appropriate simulant and test conditions, and then use the simulant to carry out the simulation migration test on the rubber gasket according to the test conditions After the migration test, take a certain amount of simulation liquid to be dried in the high-temperature oven in advance to the weight of the evaporating dish, evaporate it on the water bath, dry it in the oven at high temperature, and weigh it, Then dry and weigh until the weight is balanced The weight minus the weight of the residue of the empty evaporation dish and blank simulant can get the amount of the evaporation residue (total migration substance) in the rubber gasket 4.2 scope of application (1) it is applicable to the test of properties such as film for packaging of food, tableware, medicine, etc made of polyethylene, polypropylene, polystyrene, etc., evaporation residue of container, nonvolatile content, etc (2) It is applicable to the test of evaporation residue of gasket and gasket used for sealing bottled and canned food with natural rubber as the main raw material, such as all kinds of juice drinks, wine, condiments, etc (3) It can be used to test the evaporation residue of food container, inner coating, coating iron sheet, vegetable fiber food container and other materials which are in direct contact with food, using perchloroethylene resin as the main raw material (4) It is suitable for the evaporation residue test of the chemical reagent which can volatilize and remove the main body at the boiling water bath temperature (5) The instrument meets many national standards, such as GB / T 5009.60-2003, GB / T 5009.64-2003, GB / T 5009.68-2003, GB / T 5009.69-2008, GB / T 5009.203-2003, GB / T 9740-2008, etc 4.3 the equipment parameters can test 0 ~ 80g of residue mass, with a test accuracy of 0.3mg; the temperature control range is 100 ~ 130 ℃, with a temperature control accuracy of ± 0.2 ℃; the wind speed of hot air circulation is 0.2m/s, with a sample volume of 0 ~ 200ml; eight single samples are tested independently and in full-automatic test process, greatly improving the test efficiency; The design of automatic lifting mechanism and intermittent weighing measurement method are adopted to effectively reduce the system error; the hot air circulation system of the test chamber, the unique design of automatic temperature control and moisture removal; the weighing can be carried out directly under high temperature conditions to avoid the influence of human factors and ensure the accuracy of the test results; Three test modes, proportion, fuzzy and difference, meet different test needs of users; with the user-friendly operation interface and intelligent data processing software, it can be connected to the data sharing system of Lystem TM laboratory, and manage test results and test reports in a unified way 5 During the test (1) put about 20g rubber gasket sample into the conical flask, according to the requirements of adding 20ml simulant per gram, add simulant into the conical flask, soak the sample, place the conical flask containing the sample and simulant under the selected test conditions for migration test (2) Put the evaporating dish into the tray rack corresponding to the evaporating residue constant weight instrument according to the number for constant weight, and the instrument will automatically record the weight of each evaporating dish (3) After the migration test, take 200ml of the simulant from the conical flask and put it into two constant weight evaporating dishes respectively, and take 200ml of the blank simulant and put it into another constant weight evaporating dish for the blank test (4) Put three evaporating dishes on the water bath pot and evaporate to dryness, then transfer them to the tray rack corresponding to the evaporating residue constant weight instrument, close the test chamber door, set the reference cup and test cup number, set the drying temperature to 100 ℃, weighing interval to 1 h, select the difference test mode, the difference amount is 0.3 mg, that is, when the weight difference between the front and back sides is less than 0.3 mg It is considered to reach constant weight Click the test option to start the test (5) The equipment automatically carries out the constant weight process according to the set conditions When the constant weight condition is reached, the equipment automatically stops the test, and automatically calculates and displays the amount of evaporation residue in two test cups according to the weight of each evaporation dish 6 According to the purpose of the rubber gasket tested, the simulant selected is water, the transfer test condition is 0.5h at 60 ℃, and the evaporation residue (total transfer substance) of Zui final test sample is 11.3mg/l 7 Conclusion the content of nonvolatile small molecular substances in the rubber gasket directly contacting with food and drug is an important factor related to the safety of food and drug Ert-01 evaporation residue constant weight meter is used to detect the dissolution (total migration) of nonvolatile small molecular substances in the material On the other hand, it has the advantages of simple operation, high degree of intelligence, accurate and reliable test results, and avoids the tedious manual operation process and its impact on the test results Jinan Languang mechanical and Electrical Technology Co., Ltd is a high-tech enterprise specializing in the research and development, production and packaging testing services of packaging testing equipment It has always been committed to providing precise testing equipment and accurate testing services for global customers At present, its customer base has spread to food, medicine, packaging materials, automobiles, cosmetics, daily chemicals, chemicals, third-party testing agencies, and Scientific research institutes and many other industries and fields The more you understand, the more you trust! Labthink is looking forward to enhancing technical communication and cooperation with enterprises and institutions in the industry!
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