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    Home > Active Ingredient News > Digestive System Information > How to use omeprazole for liver and kidney damage? That's how to adjust the dose!

    How to use omeprazole for liver and kidney damage? That's how to adjust the dose!

    • Last Update: 2023-01-06
    • Source: Internet
    • Author: User
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    *For medical professionals only

    Focus on digestive health


     

    When it comes to omeprazole, many people are familiar with it, and many people "eat an omegaly capsule if their stomach is upset"
    in daily life.

    Although it is widely used in digestive tract diseases, it cannot be "eaten", especially for special groups
    .
    How to adjust the general dose of liver damage/kidney damage patients, the elderly, and children? Let's take a look!








    Adults (hepatic impairment)
    in patients with hepatic impairment (Child-Pugh A, B or C), omeprazole exposure was significantly higher than in healthy subjects
    .
    For patients with hepatic impairment, it is recommended to reduce the dose of omeprazole to 10 mg/day to maintain healing
    in erosive esophagitis.








    Adults (kidney damage).

    Despite a slight increase in the bioavailability of omeprazole in patients with chronic renal impairment (creatinine clearance 10-62mL/min/1.
    73
    m2), the course of its disposal was largely consistent
    with that of healthy subjects.
    Omeprazole metabolites are excreted mainly in urine, the rate of their excretion slows
    down with a decrease in creatinine clearance.
    Patients with renal impairment do not need to reduce the dose
    .








    Seniors
    There are no significant differences
    in the safety and efficacy of omeprazole in older and younger adults.
    No other clinical reports have found differences in response between older and younger adults, but the possibility
    of higher sensitivity to omeprazole in older adults cannot be ruled out.

    Pharmacokinetic studies have shown a decrease in omeprazole elimination in the elderly and an increase
    in bioavailability.
    The plasma clearance of omeprazole is 250 mL/min (about half that of young volunteers), and its plasma half-life is an average of 1 h, which is about twice that of healthy young volunteers
    .
    In general, older adults do not need to adjust the dose
    .








    Children
    Gastroesophageal reflux disease (GERD):
    pediatric patients aged 1 to 16 years, the dose is 5 to 10 kg, depending on body weight, and the recommended dose is 5 mg daily for up to 4 weeks
    .
    With a body weight of 10-20 kg, the recommended dose is 10 mg daily for up to 4 weeks
    .
    For body weight of 20 kg and above, the recommended dose is 20 mg daily for up to 4 weeks
    .

    ▍Acid-mediated erosive esophagitis caused by gastroesophageal reflux disease:
    pediatric patients aged 1-16 years, the dose depends on body weight, the weight is 5-10 kg, the recommended dose is 5 mg per day for 4-8 weeks
    .
    With a body weight of 10-20 kg, the recommended dose is 10 mg daily for 4-8 weeks
    .
    For body weight of 20 kg and above, the recommended dose is 20 mg daily for 4-8 weeks
    .

    For infants under 1 month to 1 year of age, the dose depends on body weight, weighing 3-5 kg, and the recommended dose is 2.
    5 mg daily for up to 6 weeks
    .
    With a body weight of 5-10 kg, the recommended dose is 5 mg daily for up to 6 weeks
    .
    For body weight of 10 kg and above, the recommended dose is 10 mg daily for up to 6 weeks
    .

    At present, the efficacy of omeprazole for more than 8 weeks in patients with erosive esophagitis (EE) has not been established
    .
    If the patient does not respond after 8 weeks of treatment, another 4 weeks of treatment
    may be given.
    If you have recurrent symptoms of EE or GERD symptoms (such as heartburn), you can take it for an additional 4 to 8 weeks
    .

    Maintenance therapy of acid-mediated erosive esophagitis caused by gastroesophageal reflux disease:
    pediatric patients aged 1-16 years, the dose depends on body weight, body weight is 5-10kg, the recommended dose is 5mg
    per day Controlled studies were no longer than 12 months
    .
    With a body weight of 10-20 kg, the recommended dose is 10 mg daily, controlled studies do not exceed 12 months
    .
    For body weight of 20 kg and above, the recommended dose is 20 mg daily, controlled studies do not exceed 12 months
    .

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    References: [1] American Geriatrics Society Beers Criteria Update Expert Panel:American Geriatrics Society 2019 updated AGS Beers Criteria(R)for potentially inappropriate medication use in older adults.
    J Am Geriatr Soc 2019; 67(4):674-694.
    [2]Product Information:PRILOSEC®(omeprazole magnesium)for delayed-release oral suspension,Covis Pharma,2020/11.
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