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On September 28 , Howson submitted an application for the listing of a class 3 generic drug called " apple acid carbody tablets " , the first in China to report production .
Cabozantinib, developed by Exelixis and Ipsos Pharmaceuticals, is a multi-target small molecule tyrosine kinase inhibitor that targets MET, VEGFR1/2/3, ROS1, RET, AXL, NTRK, KIT, etc.
first FDA approval in November 2012 for the treatment of progressive, metastatic thyroid myelin-like cancer (MTC).
April 2016, the FDA approved cabotinib for the first time for second-line treatment in patients with advanced renal cell carcinoma (RCC) who had previously received anti-angiogenesis treatment, based on the results of the Cabotinib VS Evimox clinical trial (research code METEOR).
December 2017, the FDA further approved Cabotinib for first-line treatment in patients with advanced renal cell carcinoma (RCC) based on the results of the Cabotinib VS Schoiniene Clinical Trial (research code CABOSUN).
January 2019, the FDA officially approved Cabotinib for second-line treatment in patients with advanced liver cancer (the adaptation is approved based on clinical research code-named CELESTIAL).
Currently, Cabotinib has been clinically and has shown good therapeutic results in a variety of solid tumors, including thyroid myelin, kidney, non-small cell lung, liver, prostate, breast, ovarian, bowel, and many other solid tumors.
because of its wide-ranging effectiveness for a variety of cancers, cabotinib is known as the "golden oil" in targeted drugs and has broad-spectrum cancer resistance.
, however, the original research has not been listed in China, according to insight database, Cabozantinib (XL184) and Atezolizumab drugs for advanced hepatocellular carcinoma clinical has entered phase 3.
Although the original research has not been listed, many domestic generic drug companies have long since begun to lay out, Insight database shows that, in addition to Howson, Zhengda Tianqing, Osaikang, Jiangsu Weikel, Xiansheng Dongyuan, etc. are already doing biological equivalent testing.
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