Huang Qiang's group published a new method for de novo design of nucleic acid aptamers

<>

Recently, Biosensors & Bioelectronics, an authoritative academic journal in the field of biosensors, published online a research paper on the molecular design of nucleic acid aptamers by Professor Huang Qiang's group from the School of Life Sciences of Fudan University and the State Key Laboratory of Genetic Engineering : De novo design of DNA aptamers that target okadaic acid (OA) by docking-then-assembling of single nucleotide.

Biosensors have the characteristics of high sensitivity, strong specificity, and simple operati.

In the research, Professor Huang Qiang's research group innovatively proposed the de novo design method of nucleic acid aptamers of "single nucleotide docking and assembly" using computational structural biology technology and the concept of drug molecule fragment design, and successfully designed the High-affinity and high-specificity nucleic acid aptamers of okadaic ac.

FigureOkadaic acid aptamers designed by single-nucleotide docking post-assembly method

Song Menghua, a doctoral student from the School of Life Sciences, is the first author of the paper, Professor Huang Qiang is the corresponding author, and Li Yuanyuan, .

The link to the paper is: https://