Huang Yubin and Zhou Dongfang, associate researchers of Changchun Yinghua Institute, Chinese Academy of Sciences, applied functional fiber / sponge composite to prevent recurrence and metastasis of tumor after operation

Surgical resection is the main method of early clinical treatment of tumor, but it is easy to recur and metastasize Clinical research shows that the residual tumor cells at the surgical margin are the main cause of tumor recurrence; meanwhile, the inevitable bleeding during tumor resection can spread the fallen tumor cells into the blood of the surgical site, and even enter the systemic blood circulation to increase the circulating tumor cell level, thus improving the risk of tumor recurrence in situ and distant metastasis Recently, researchers Huang Yubin and Zhou Dongfang from Changchun Institute of Applied Chemistry, Chinese Academy of Sciences designed a sandwich structure fiber / sponge composite with functions of in situ chemotherapy and hemostasis, which is very close to the clinical application, and used as the original implantation material for the prevention of postoperative recurrence and metastasis (advanced materials, 2018 , 30 , 1803217） 。 First, the PLGA/ Gelatin Nanofiber fabric loaded with anticancer drug cisplatin was prepared by electrospinning technology Then the fiber was placed between gelatin / chitosan gel solution and freeze-dried to obtain sandwich structure fiber / sponge composite The sandwich structure fiber/ After the sponge complex is implanted into the tumor site in situ, the outer sponge can quickly and effectively stop bleeding and absorb the tumor cells shed during the operation; meanwhile, the inner nano electrospun fiber can slow release cisplatin for a long time, and continuously kill the exfoliated tumor cells absorbed in the sponge and the remaining tumor cells at the surgical margin, so as to achieve excellent prevention of in situ recurrence and distant metastasis The fiber / sponge composite is a very good ductile material, which can be easily folded and used for bleeding sites, especially those not easily contacted The hemostasis experiments in vitro and in vivo also show that the hemostasis effect of the composite is better than that of the medical gelatin sponge The research shows that the sandwich structure fiber / sponge composite, which has the functions of in situ chemotherapy and hemostasis, can not only effectively prevent tumor recurrence in situ and distant metastasis, but also reduce the high toxicity and side effects of postoperative medication and treatment, and has a very good clinical application prospect The above research results were published in advanced materials under the title of "sandwich like fibers / sport composite combining chemotherapy and emphasis for efficient post operational prevention of more curriculum and metadata" Zhang Zhiyun, Ph.D candidate of Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, and Kuang gaizhen, Ph.D candidate jointly cultivated by Xi'an Jiaotong University As co first author The above research work is supported by the National Natural Science Foundation of China and the science and Technology Department of Jilin Province.