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Hum Vaccin Immunother: The persistence of immunogenicity of hepatitis A vaccines Healive® and Havrix® in children: 11-year follow-up observation results

 Last Update: 2021-07-28
 Source: Internet
 Author: User

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In China, hepatitis A vaccine has been used in large-scale and routine public vaccination programs
.

Long-term follow-up studies are needed to determine the duration of protection and the need for enhanced vaccination

400 healthy children were randomly assigned at a 3:1 ratio to receive two doses of Healive or Havrix at 0 and 6 months
.

The current study reports new data 11 years after immunization to show the persistence of antibodies

Childhood Immunization

The results showed that compared with Havrix, Healive had significantly higher GMCs at 1, 6, 7, 66, 112, and 138 months after vaccination
.

In addition, the GMCs obtained using the sensitivity analysis are very similar to the GMCs obtained using the original model

In summary, in children 11 years after complete immunization, Healive is more immunogenic than Havrix
.

Predictive analysis shows that the duration of the antibodies of the two vaccines is at least 30 years

Original source:

Yongji Wang, et al.

Immunogenicity persistence in children of hepatitis A vaccines Healive® and Havrix®: 11 years follow-up and long-term prediction

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