echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Study of Nervous System > HUMAN BRAIN MAPPING: Deformation of the right anterior hippocampus is associated with genetic risk for substance use disorders

    HUMAN BRAIN MAPPING: Deformation of the right anterior hippocampus is associated with genetic risk for substance use disorders

    • Last Update: 2022-05-24
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Substance use disorder (SUD) is prevalent in SUD (FH+) individuals with a family history (FH) , and this increased risk of SUD is likely to be transmitted through complex genetic and environmental / learning mechanisms .
    However, the neural correlates of this transmission remain poorly understood, in part because it is difficult to distinguish between neural signatures resulting from home transmission and substance use .
    Although the size and shape of subcortical structures ( SSS ) have been shown to be heritable, these structures, particularly the globus pallidus, putamen, nucleus accumbens, and hippocampus, have also been implicated in substance use disorders .
    However, it is unclear whether these anatomical differences precede or result from drug use .




    Substance use disorder (SUD) is prevalent in SUD (FH+) individuals with a family history (FH) , and this increased risk of SUD is likely to be transmitted through complex genetic and environmental / learning mechanisms .
    However, the neural correlates of this transmission remain poorly understood, in part because it is difficult to distinguish between neural signatures resulting from home transmission and substance use .
    Although the size and shape of subcortical structures ( SSS ) have been shown to be heritable, these structures, particularly the globus pallidus, putamen, nucleus accumbens, and hippocampus, have also been associated with substance use disorders .
    However, it is unclear whether these anatomical differences precede or result from drug use .




    Zhishun Wang et al .
    published an article entitled
    Shapes of subcortical structures in adolescents with and without familial history of substance use disorder in
    HUMAN BRAIN MAPPING magazine , and investigated whether the volume and SSS of adolescents with family history of SUD (FH+) were related to those without such families History (FH-) adolescents are different .

    Zhishun Wang et al .
    published an article entitled
    Shapes of subcortical structures in adolescents with and without familial history of substance use disorder in
    HUMAN BRAIN MAPPING magazine , and investigated whether the volume and SSS of adolescents with family history of SUD (FH+) were related to those without such families History (FH-) adolescents are different .

    Since the risk of SUD is related to anxiety and impulsivity, they also investigated the correlation between these psychological characteristics and volume /SSS .
    Using structural MRI and FSL software to segment subcortical structures, SSS and volume metrics were obtained in 64 FH + and 58 FH- adolescents .
    Between-group differences in volume and SSS were investigated, as well as the correlation between volume /SSS and trait anxiety and impulsivity .



    Since the risk of SUD is related to anxiety and impulsivity, they also investigated the correlation between these psychological characteristics and volume /SSS .
    Using structural MRI and FSL software to segment subcortical structures, SSS and volume metrics were obtained in 64 FH + and 58 FH- adolescents .
    Between-group differences in volume and SSS were investigated, as well as the correlation between volume /SSS and trait anxiety and impulsivity .



    The study found

    The study found
    • The shape of the right anterior hippocampus was markedly inwardly deformed in FH+ adolescents compared with FH- adolescents , whereas the volume of this structure did not differ between groups .

  • The shape of the right anterior hippocampus was markedly inwardly deformed in FH+ adolescents compared with FH- adolescents , whereas the volume of this structure did not differ between groups .

  • The shape of the right anterior hippocampus was markedly inwardly deformed in FH+ adolescents compared with FH- adolescents , whereas the volume of this structure did not differ between groups .

    Results of hippocampal shape analysis in FH+ group and FH- group

    Results of hippocampal shape analysis in FH+ group and FH- group

    There were no between-group differences in the shape and volume of other subcortical structures
    .

    There were no between-group differences in the shape and volume of other subcortical structures
    .
    • Left hippocampal shape in FH+ adolescents was positively correlated with both trait anxiety and impulsivity, whereas hippocampal shape in FH+ adolescents was negatively correlated with SSS .

  • Left hippocampal shape in FH+ adolescents was positively correlated with both trait anxiety and impulsivity, whereas hippocampal shape in FH+ adolescents was negatively correlated with SSS .

  • Left hippocampal shape in FH+ adolescents was positively correlated with both trait anxiety and impulsivity, whereas hippocampal shape in FH+ adolescents was negatively correlated with SSS .

    Correlation analysis of shape-behavior scores in FH+ group

    Correlation analysis of shape-behavior scores in FH+ group

    The research team believes that SSS appears to capture topographical features that traditional volumetric analysis cannot
    .

    The research team believes that SSS appears to capture topographical features that traditional volumetric analysis cannot
    .

    Zhishun Wang's study demonstrated that introversion of the right anterior hippocampus in FH+ adolescents may be associated with an increased risk of SUD due to behavioral dysregulation in FH+ offspring .
    Hippocampal shape also showed opposite correlation patterns in anxiety and impulsivity scores in FH+ and FH- adolescents .
    These new findings may reveal neural correlates of increased familial susceptibility to SUD that traditional volumetric analyses have failed to capture .
    This suggests that subcortical shape analysis appears to capture anatomical - clinical correlations better than traditional volumetric analysis .
    Importantly, since SSS exhibits strong heritability but is also sensitive to environmental factors, these imaging findings may represent neural correlates of familial transmission of SUD risk .





    Zhishun Wang's research proves FH+ Zhishun Wang's research demonstrates that introversion of the adolescent right anterior hippocampus may be associated with an increased risk of SUD due to behavioral dysregulation in FH+ offspring .
    Hippocampal shape also showed opposite correlation patterns in anxiety and impulsivity scores in FH+ and FH- adolescents .
    These new findings may reveal neural correlates of increased familial susceptibility to SUD that traditional volumetric analyses have failed to capture .
    This suggests that subcortical shape analysis appears to capture anatomy better than traditional volumetric analysis.
    Subcortical
    shape analysis appears to capture anatomically - clinically relevant clinical relevance better than traditional volumetric analysis .
    Importantly, since SSS SSS exhibits strong heritability but is also sensitive to environmental factors, these imaging findings may represent a strong heritability but also sensitivity to environmental factors that these imaging The results may represent neural correlates of familial transmission of SUD risk for SUD .





    original source

    original source original source

    Wang Z , Rodriguez Moreno DV , Cycowicz YM , et al.
    Shapes of Subcortical Structures in Adolescents With and Without Familial History of Substance Use Disorder[J].
    Social Science Electronic Publishing.

    Wang Z , Rodriguez Moreno DV , Cycowicz YM , et al.
    Shapes of Subcortical Structures in Adolescents With and Without Familial History of Substance Use Disorder[J].
    Social Science Electronic Publishing.
    Wang Z , Rodriguez Moreno DV , Cycowicz YM , et al.
    Shapes of Subcortical Structures in Adolescents With and Without Familial History of Substance Use Disorder[J].
    Social Science Electronic Publishing.


    Leave a message here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.