Human calcium channel CaV3.3 gating mechanism and drug recognition mechanism

Calcium ion (Ca ²⁺ ) is an important second messenger in cells and is involved in many important physiological processes such as nerve signal transmission, muscle contraction, regulation of cell proliferation, apoptosis and differentiation

On April 19, 2022, Zhao Yan's research group from the Institute of Biophysics, Chinese Academy of Sciences and Huang Zhuo's research group from the School of Pharmacy, Peking University collaborated on a collaborative publication entitled "Structure, gating, and pharmacology of human Ca _{V " in the journal "} Nature communications ".

The researchers found that the T-type calcium channel Ca _V 3.

The study also solved the high-resolution structures of Ca _V 3.

Figure 1: Key elements of low-voltage activation of the T-type calcium channel Ca _V 3.

Researcher Zhao Yan from the Institute of Biophysics, Chinese Academy of Sciences is the corresponding author of this research paper

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(Contributed by Zhao Yan's research group)