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    Home > Active Ingredient News > Drugs Articles > Human or developed drugs to control abnormal gene expression

    Human or developed drugs to control abnormal gene expression

    • Last Update: 2017-09-12
    • Source: Internet
    • Author: User
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    [China Pharmaceutical network industry trends] it is reported that researchers from Tsinghua University, Northwestern University, University of Texas at Dallas and University of Miami in China have found a mechanism to regulate a protein that affects transcription This discovery may lead to the development of drugs that control the abnormal expression of genes Relevant research results were published online in Science Journal on August 31, 2017, and the paper title was "Paf1 regulation of promoter proximal pause release via enhancer activation" The corresponding author is Professor Ali shilatifard, director of Biochemistry and molecular genetics, Feinberg School of medicine, Northwestern University The author of the paper is Fei Chen, a doctoral student in shilatifard laboratory When factors including RNA polymerase II (pol II) are assembled on a DNA sequence called a promoter located upstream of the gene, the gene transcription process begins Pol II transcribes protein coding genes In a study published in the journal Cell in 2015, shilatifard, Chen and other members of shilatifard's laboratory confirmed how protein Paf1 (pol-ii-associated factor 1) causes pol-ii to pause on some promoters, thus inhibiting transcription initiation (cell, DOI: 10.1016 / J.Cell 2015.07.042) "Pausing promoters and then releasing them at the right time during development is very important to properly regulate the expression of multiple genes at different stages of development," shilatifard said Although that study determined that removing Paf1 would release Pol II from its suspended state, it did not reveal the specific mechanism of Paf1 It wasn't until Chen started exploring the role of transcription enhancers that he and his collaborators identified the link According to previous studies, the role of these enhancers is to increase the probability that a gene is transcribed (often in a tissue-specific way) "The function of these enhancers is to ensure that a gene is expressed in eye cells rather than in skin cells," shilatifard said In this new study, Chen found that removing Paf1 regulated the activation of enhancer regions, leading to pauses and releases "There's a lot of research on enhancer regulation, there's a lot of research on pause regulation, but we're confirming that these two steps are related," Chen said According to shilatifard, these enhancers may be key to stopping and treating cancer "We know that enhancers mutate in a lot of cancers," he said We believe that the next step will be to develop a number of drugs, which may be used to study the transcription process " According to shilatifard, drugs that regulate transcription pauses and releases may represent a promising approach to development in the future, but much remains to be done "Given that we found Paf1's function in enhancer activation and Pol II pause / release, we were able to identify inhibitors, activators and enhancers of this process through screening, and then continue to study the diseases caused by this process when it is subject to abnormal regulation," shilatifard said He added, "we know that pauses are essential for development and that abnormal regulation of pauses can lead to disease Now, we will continue to work on it " (bio.com) reference: Fei Xavier Chen, Peng Xie, Clayton K collages et al Paf1 regulation of promoter proximal pause release via enhancer activation Science, published online: 31 Aug 2017, Doi: 10.1126/science.aan3269 original title: Science: reveal gene transcription pause mechanism Seize the opportunity of pharmaceutical machinery and equipment industry, please download app (Pharma, Android version)!
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