Human stem cells create 3D micro-brains.

Scientists in the United States have used human stem cells to create a 3D "micro-brain" that finds it structurally and functionally closer to the real brain than the widely used 2D model, according to the latest issue of Cell.
model will help scientists better understand brain development and neurological disorders such as Alzheimer's or schizophrenia.
, director of the Genetic Analysis Laboratory at the Sock Institute in the United States, said the cultivation of human brain cells into tiny 3D organs was a major breakthrough.
with a model that is structurally closest to the actual brain, scientists can look at its genetic and prescient genetic characteristics to find out what is closest to the actual brain.
years, cell biologists have chemically encouraged embryonic stem cells to develop (differentiate) into various types of brain cells in petri dishes.
researchers can gather a lot of information from these single-layer cells, but these real brain tissues are 2D.
2013, European researchers developed a new way to grow embryonic brain cells in 3D gels and differentiate them into multi-layered brain cells similar to real brains.
, however, the functional differences between the lab-cultured mini-brains, known as organoids, and the real brains are unclear.
Solke Institute compared organs in the early stages of brain development with real brain tissue at the same stage.
researchers found that organoids are closer to the real brain in terms of cell differentiation than two-dimensional models, i.e. they develop along an early developmental timeline that is very similar to the real brain.
to create organoids for analysis, the team used H9 human embryonic cell lines to add the right chemicals to induce these cells to grow along a neurodevelopmental path path for 60 days.
, they analyzed the overt genetic characteristics of organs.
of cells, which are affected by environmental factors such as diet or stress, are increasingly thought to be associated with diseases such as development and schizophrenia.
researchers say no one has ever sequenced the visual genome of brain tissue before.
such assessments are particularly important for understanding brain development, especially the eventual use of these tissues to develop treatments for neurological disorders.
source: Cop China.