Hunting: A new mechanism for the diversity of transcripts.

Transcript diversity plays an important role in organic body function diversity, but the mechanism and biological significance of it is still unclear.
recently, the Zhan Xiangjiang Laboratory of the Institute of Zoology of the Chinese Academy of Sciences revealed a new mechanism for the diversity of transcripts by analyzing the blood transcripts and methylation groups of the falcons, the chickens and the multi-tissue transcription groups of mice.
the study found that genes that expressed more tended to have more transcripts.
analysis of the four most expressed hemoglobin genes in the hunter's blood showed that, although they had no more than three exons, they could produce hundreds of different transcripts through variable shear, and that most of the shears occurred not on existing genome sphenossites, but related to newly created shear sites. further research
showed that these new shear sites were caused by mutations in DNA during transcription (rcribion-associated mutation, TAM).
this result changes the industry's widely accepted view that RNA editing is the primary way new shear sites are produced."
, the study also analyzed the spatial relationship between DNA methylation and TAM and found that DNA methylation during transcription may inhibit the production of TAM, suggesting that DNA methylation not only regulates gene expression, but also affects the generation of new shear sites.
discovery expands the academic community's understanding of the function of DNA methylation.
In addition, the study, through the analysis of the differences in the transcription of hemoglobin in the Tibetan Plateau and lowland populations, found for the first time that the Population of the Qinghai-Tibet Plateau has more high-level expression of hemoglobin transcripts, which may help the falcons better adapt to the low-oxygen environment of the plateau.
the study is the first to clarify the main way new variable shear sites are generated by TAM, and suggests that RNA diversity caused by TAM may provide another strategy for adaptive evolution of species. On February 7,
, the results of the study were published in Molecular Biology and Evolution, based on the title of TheRIon-Associated Mutation Segeny-Genes-a major new source of selectable. the first author of the
article is Pan Shengkai, a doctoral student at the Institute of Animals, and researcher Zhan Xiangjiang is the author of the newsletter.
research has been supported by the Strategic Leading Science and Technology Special (B), the National Key Research and Development Program of the Chinese Academy of Sciences, the National Natural Science Foundation of China Youth Fund for Excellence, and the Center for Excellence in Animal Evolution and Genetic Frontiers of the Chinese Academy of Sciences.
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