Hypertension: Anti-hypertensive drugs and risk of depression.

High blood pressure, cardiovascular disease, and cerebrovascular disease are associated with an increased risk of depression, but it is not clear whether treatment with antihypertensive drugs reduces or increases this risk.
role of specific antidepressants is also unknown.
, researchers used the Danish Population Registry to systematically investigate whether 41 of the most commonly used antihypertensive drugs were associated with a risk of depression, according to a study published recently in hypertensive journal Hypertension.
participants were included in the study in January 2005 and followed up until December 2015.
included two different outcome indicators: (1) being diagnosed with depression as an inpatient or outpatient in a psychiatric hospital, and (2) diagnosing depression or using antidepressants.
researchers found that the continued use of angiosin drugs, calcium antagonists and beta blockers was associated with a significant reduction in the risk of depression, compared with the use of diuretics.
drugs associated with depression reduction include two of the 16 angiosin drugs: Inapri and Remipri.
of the 10 calcium antagonists: ammonia chloroprene, virapami and vilapami compounds;
drugs were associated with an increased risk of depression.
, data based on actual population data showed that the continued use of nine anti-depressants had a positive effect on the risk of depression.
this evidence should be used to guide prescriptions for patients at risk of depression, including those with previous depression or anxiety disorders, and patients with a family history of depression.
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