Hypertension: Reduced sodium intake increases circulating short-chain fatty acids in patients with untreated hypertension

A high-sodium diet may regulate the gut microbiomeGiven that short-chain fatty acids (SCFA) in the cycle come from gut microbes, researchers recently published a study in the journal Hypertension, a cardiovascular authority, to test the hypothesis that moderate sodium intake alters sCFA concentrations in the cycle in untreated patients with high blood pressure, and that this change is associated with lower blood pressure and improved cardiovascular phenotypesthe randomized, double-blind, placebo-controlled cross-test with slow sodium or placebo tablet salt reduction included 145 participants (42 percent black, 19 percent asian and 34 percent of women), and slow sodium or placebo tablets for six weeks eachTargeted cyclic SCFA analysis was performed in the paired serum samples and collected at the end of each cycle as an indicator of all outcomessodium reduction increased all eight SCFA, of which the increase in 2-methyl butyric acid, butyric acid, isobutyric acid and polyric acid was statistically significant (Ps 0.05)In addition, the increase in SCFA was associated with lower blood pressure and improved arterial complianceSodium reduction was associated with sodium reductionThe effects of CFAs had significant gender differences (Ps 0.05)When stratified by sex, the increase in butyric acid, hebutyric acid, isoprene and polyric acid was only significant in women (Ps 0.05) and not significantly in men (Ps 0.05)In women, changes in isopyrate, isoprene, and 2-methylbuterate were negatively correlated with lower blood pressure (Ps 0.05)The increase in the acid content was associated with the decrease in the pulse wave velocity of the neck strands (P-0.040)the results of the study, which showed that a reduction in sodium intake in the diet increased sCFA in circulation, and these results supported the dietary sodium intake that may affect the human gut microbiomeThere are gender differences in SCFA's response to sodium reductionIn addition, increased SCFA is associated with lower blood pressure and improved arterial compliance