Hypoxia promotes linear ubiquitination of AGO2 to regulate tumorigenesis and development

Tumor hypoxic microenvironment is one of the most significant characteristics of solid tumors

On September 13, 2021, the team of Yu Jianxiu /Cheng Jinke/Chen Guoqiang from Shanghai Jiaotong University School of Medicine published in Nature Communications the latest research results titled Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells

miRNA is a type of non-coding single-stranded small RNA with a length of about 19-25 nt and a conservative sequence that is widely present in eukaryotes.

In this work, the author first found through RIP-seq/RNA-seq/miRNA-seq detection that under hypoxic conditions, the miRNA pathway is inhibited, and the degradation of its target mRNA is blocked, thereby showing an overall accumulation

In summary, this study first puts forward the view that tumor hypoxia microenvironment regulates mRNA homeostasis, and reveals the dynamic regulation mechanism of hypoxia on the regulatory network of miRNAs from a new perspective, providing new ideas for tumor research

Postdoctoral fellow Zhang Hailong , associate researcher Zhao Xian, and postdoctoral fellow Guo Yanmin of the Department of Biochemistry and Cell Molecular Biology, Shanghai Jiao Tong University School of Medicine are the co-first authors of the paper.

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