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Ulcerative colitis (UC) is a chronic inflammatory disease that typically begins in the rectum and usually extends proximally
.
Colorectal neoplasm (CRN) is a dreaded complication of UC, and risk factors for CRN include family history of colorectal cancer (CRC), coexisting primary sclerosing cholangitis (PSC), disease extent (outside the rectum), and Longer duration of disease history,
Ulcerative Colitis FDA
The researchers conducted a retrospective analysis of 495 patients with confirmed UC from a tertiary referral center
.
Patients were classified according to their best histological assessment obtained over the course of their disease: histologically normalized, histologically quiescent, or histologically active
diagnosis
The findings showed that in multivariate analysis, patients with histological normalization had a statistically lower incidence of dysplasia at any time point throughout the duration of UC compared with patients with persistent histological inflammation ( [aHR].
], 0.
32; 95% [CI], 0.
13-0.
81), but not in histologically quiescent patients (aHR, 0.
52; 95% CI, 0.
25-1.
10)
.
When assessing the time to histologically normalized, histologically quiescent, or 8 years after UC diagnosis in patients with persistent histological activity, the researchers found that histologically normalized patients subsequently developed dysplastic changes compared with non-normalized patients.
statistics
This study demonstrates that histological normalization is associated with a reduced risk of subsequent developmental abnormalities in patients with UC compared with patients without histological normalization
.
.
Original source:
Original source:Seth R Shaffer.
Seth R Shaffer.
Et al.
Achieving Histologic Normalization in Ulcerative Colitis Is Associated With a Reduced Risk of Subsequent Dysplasia.
Inflammatory Bowel Diseases.
2022.
Achieving Histologic Normalization in Ulcerative Colitis Is Associated With a Reduced Risk of Subsequent Dysplasia.
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