IBD: Clostridium difficile infection can significantly reduce the time of first bowel removal in children with Crohn's disease.

Background C. difficile infection and fixation are common in pediatric Crohn's disease (CD), and the bacteria and its incurability to cure, the purpose of this study is to detect the relationship between Clostridium difficile positive and bowel resection surgery in children, and to try to find the characteristics of Clostridium difficile carriers and surgically related microbiomes.
method researchers designed a retrospective single-center study that analyzed the association between C. difficile testing and enterosection surgery in 75 CD-child patients.
the microbiome variants of Clostridium difficile carrying or surgical history stratified were tested on patients with fecal clostridium and fecal samples using gun gun-gun macro genome sequencing. the proportion of enterothetic surgery in patients without C. difficile was 21%
and 67% in patients with C. difficile (P - 0.003).
According to kaplan-Meier survival model, the risk ratio for patients who tested positive for Clostridium difficile in the first year of diagnosis was 4.4 (95% CI, 1.2-16.2; P - 0.00). this association is confirmed by the
multivariate logistic regression analysis (OR16.2; 95% CI is 2.2-120; P is 0.006).
in patients who underwent surgery, the difference in microbial richness and metabolic pathways observed was greater than that of Clostridium difficile carriers.
the first year of diagnosis, the positive test for Clostridium difficile was associated with a decrease in the time of the first bowel resection surgery in pediatric Crohn's disease.
difficult to identify the biosynthetic consumption of myothemygin carried by patients may increase the risk of surgery.
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