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The interplay between gut commensals and host immune function is increasingly recognized as playing a key role in the pathological process of many inflammatory diseases, including Crohn's disease (CD)
.
Although CD-specific genetic mutations are associated with dysregulation of the gut immune response, CD incidence rates vary by as much as 50% between identical twins, suggesting that other factors are also involved
The interplay between gut commensals and host immune function is increasingly recognized as playing a key role in the pathological process of many inflammatory diseases, including Crohn's disease (CD)
diagnosis
During a median follow-up of 9.
5 years, CD was diagnosed in 208 of 979,039 children
.
Antibiotic use in the first year of life was associated with a higher risk of CD (adjusted hazard ratio, 1.
Figure: Antibiotic use and risk of Crohn's disease
Using a large population, this study found that the use of antibiotics in the first year of life was associated with a modestly increased risk of CD, but the absolute risk remained very low
.
.
Original source:
Anders Mark-Christensen.
Early-Life Exposure to Antibiotics and Risk for Crohn's Disease: A Nationwide Danish Birth Cohort Study.
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