IBD: Fecal calprotectin is very effective in determining whether the endoscopic ulcer of Crohn's disease is relieved

Crohn's disease (CD) is a chronic, progressive and disabling disease that can cause intestinal damage and significantly change the quality of life of patients
.

In the past decade, the therapeutic target of CD has evolved from clinical remission to more changes in objective markers of intestinal inflammation and prevention of complications

Crohn's disease (CD) is a chronic, progressive and disabling disease that can cause intestinal damage and significantly change the quality of life of patients

 

A total of 123 patients with CD were included in this study.
These patients underwent Fcal measurement and ileocolonoscopy within 1 month without any other therapeutic intervention during this period
.

The receiver operating characteristic curve (ROC) is used to determine the optimal Fcal threshold for detecting endoscopic ulcers

 

The results of the study showed that patients with simple ileal CD (L1 group) (P = 0.
025) and patients with ileocolonic and colonic CD (L2-L3 group) (P <0.
001) with endoscopic ulcers had significantly higher average Fcal levels
.

Using ROC curve calculations, it was found that Fcal >200 µg/g was the best threshold for detecting endoscopic ulcers in the L1 group (sensitivity = 75.

Figure: The probability of fecal calprotectin in judging whether the endoscopic ulcer of Crohn's disease is relieved

This study confirmed that fecal calprotectin is very effective for detecting endoscopic ulcers regardless of the location of the CD, but a lower cut-off value is required for patients with simple ileal involvement
.

This study confirmed that fecal calprotectin is very effective for detecting endoscopic ulcers regardless of the location of the CD, but a lower cut-off value is required for patients with simple ileal involvement
.

 

 

Original source:

Anthony Buisson.

Fecal Calprotectin Is Highly Effective to Detect Endoscopic Ulcerations in Crohn's Disease Regardless of Disease Location.
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