IBD: IgA levels and intestinal flora in feces are regulated by NK-T cells

BACKGROUND: Intestinal flora is a key factor in supporting the steady state of the host body and the development of the immune systemThe relationship between the microbiome and immunity is complex, where the microbiome contributes to the development of immune cells, and immunity affects the composition of microorganismsIn this case, natural lymphoin T cells (NKT cells) are different T lymphocytes that work in intestinal immunity and are influenced by gut microbesIn this study, the researchers studied the relationship between NKT cells (iNKT) and intestinal steady stateresults: The researchers found lower levels of fecal IgA in iNKT-KO-defective mice(iNKT-KO), changes in the composition of intestinal flora, and increased the number of pylorisThe absence of iNKT cells also affected TGF-beta1 levels and plasma cells, which were significantly reduced in knockout (KO) miceIn addition, colonitis in iNKT-KO mice worsened when treated with sodium glucan sulfate colitis compared to wild -type (WT) miceTo further clarify the effect of iNKT cells on the dynamic balance of the intestines, the researchers transferred iNKT cells to KO mice and then transferred them to the colitis stageThe metastasis of iNKT cells improved colitis and restored fecal IgA levels and intestinal floraConclusion: This study shows that intestinal NKT cells are an important regulator of intestinal stability, and the composition of intestinal flora may be a potential target for the treatment of inflammatory bowel disease