IBD: Mononucleosis is a biomarker of inflammatory bowel disease severity

Ulcerative colitis (UC) and Crohn's disease (CD) are a heterogeneous group of immune -mediated chronic gastrointestinal inflammatory bowel diseases (IBD)
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In UC and CD, the clinical phenotype is distinct, with different disease trajectories, outcomes, and responses to therapy

Ulcerative colitis (UC) and Crohn's disease (CD) are a heterogeneous group of immune -mediated chronic gastrointestinal inflammatory bowel diseases (IBD)

To do this, the researchers collected clinical data from patients with inflammatory bowel disease who were treated in healthcare settings between January 2010 and December 2015
.

Mononucleosis was defined as absolute monocyte counts above the upper limit of normal, and the association between IBD patients with mononucleosis and those without mononucleosis was then compared by disease type in all patients sex

 

A total of 1290 patients with IBD (64.
1% with Crohn's disease; 35.
9% with ulcerative colitis ) (mean age 46.
4 years; 52.
6% women) were included in this study
.

The researchers found symptoms of mononucleosis in 399 (30.

Ulcerative colitis quality of life

Figure: Association of mononucleosis with surgery and hospitalization in patients with inflammatory bowel disease

The results of this study confirm that IBD patients with mononucleosis, regardless of disease type, are at risk for worse clinical outcomes, hospitalization, surgery, and ED use
.

Peripheral mononucleosis may represent a routinely available biomarker for distinct subgroups with severe disease

The results of this study confirm that IBD patients with mononucleosis, regardless of disease type, are at risk for worse clinical outcomes, hospitalization, surgery, and ED use

Alyce Anderson.

Monocytosis Is a Biomarker of Severity in Inflammatory Bowel Disease: Analysis of a 6-Year Prospective Natural History Registry.
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