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BACKGROUND: Although several studies have linked the use of nonsteroidal anti-inflammatory drugs to the onset of disease in patients with inflammatory bowel disease (IBD), little is known about the effects of daily aspirin use on clinical outcomes in patients with IBDThe study looked at the effects of daily aspirin use on the clinical outcomes of patients with inflammatory bowel disease
methods: The researchers reviewed the data collected on the registration of patients with IBD from May 2008 to June 2015Patients who used aspirin daily were matched 1:4 by age, sex, disease, disease location and whether aspirin was presentThe final analysis included patients who had followed for at least 18 monthsThe main observations were IBD-related hospitalizations during follow-up, IBD-related surgery, and the need for corticosteroid therapyResults: This study included a total of 764 cases of IBD patients, of which 174 were taking aspirinThere was no statistical difference between the two groups in terms of age, sex, diagnosis (Crohn's disease and ulcerative colitis), duration of disease, Charson comorbidity index, smoking status, drug use or baseline C-reactive proteinAfter controlling covariates and follow-up times across the population, the use of aspirin was not related to the risk of hospitalization for IBD-related complications (odds of 1.46;conclusion: The use of aspirin does not affect the primary clinical outcomes of PATIENTs with IBDAlthough the effects of aspirin on mucous membrane inflammation were not directly assessed in this study, these findings support the safety of daily aspirin use in this population