echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Digestive System Information > IBD: The relationship between dietary fatty acid intake and the development of ulcerative colitis

    IBD: The relationship between dietary fatty acid intake and the development of ulcerative colitis

    • Last Update: 2021-05-07
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

         In Asian countries, the increase in the number of patients with medsci.
    cn/course/search.
    do?w=%E6%BA%83%E7%96%A1%E6%80%A7%E7%BB%93%E8%82%A0%E7%82%8E">ulcerative colitis (UC) may be related to the gradual popularity of westernized diets.
    A diet rich in fatty acids and insufficient dietary fiber can induce intestinal microbial malnutrition and inflammation.
    Among all fatty acids, n-6 polyunsaturated fatty acids (n-6 PUFA), such as linoleic acid and arachidonic acid (AA), are metabolized to produce pro-inflammatory eicosanoids, such as prostaglandins and leukotrienes.
    Thromboxane and epoxyeicosatrienoic acid.
    These eicosanoids are involved in the inflammatory process, but n-3 polyunsaturated fatty acids (n-3 PUFA), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), can prevent AA Converted into pro-inflammatory eicosanoids.
    In particular, n-3 PUFA can inhibit inflammatory chemotaxis by acting on white blood cells, and by inhibiting the production of other inflammatory cytokines and T cell reactivity.
    In Japan, the relationship between dietary intake of fatty acids and the risk of UC has not yet been clearly studied.
    Therefore, this study aims to explore the relationship between fatty acid intake and the occurrence of ulcerative colitis in Japanese patients.

    In Asian countries, the increase in the number of patients with medsci.
    cn/course/search.
    do?w=%E6%BA%83%E7%96%A1%E6%80%A7%E7%BB%93%E8%82%A0%E7%82%8E">ulcerative colitis (UC) may be related to the gradual popularity of westernized diets.
    A diet rich in fatty acids and insufficient dietary fiber can induce intestinal microbial malnutrition and inflammation.
    medsci.
    cn/course/search.
    do?w=%E6%BA%83%E7%96%A1%E6%80%A7%E7%BB%93%E8%82%A0%E7%82%8E">Ulcerative colitis thrombus

     

          From 2008 to 2014, researchers conducted a case-control study on 83 newly diagnosed UC patients and 128 age- and gender-matched control patients in our hospital.
    The self-diet analysis table was used to quantitatively
    screen the intake of fatty acids in the diet during the previous month and one year .

    Diagnostic screening

     

          The results of the study show that approximately 92% of patients have experienced clinical manifestations of UC within one year.
    Patients who consumed n-6/n-3 polyunsaturated fatty acids with a ratio of ≥5.
    2 in a year had a significantly lower risk of UC ([OR] = 0.
    26; 95%[CI]], 0.
    10-0.
    68).
    On the contrary, the diet is rich in docosahexaenoic acid (OR = 7.
    22; 95% CI, 2.
    09-24.
    95), eicosapentaenoic acid (OR = 6.
    91; 95% CI, 1.
    88-25.
    44) and twenty A significantly higher risk of UC was observed in patients with dioxopentaenoic acid (OR = 4.
    83; 95% CI, 1.
    56-14.
    95).

    Figure: The influence of different unsaturated fatty acids on the incidence of UC

     

          This study confirmed that the increase in the intake of n-3 / n-6 polyunsaturated fatty acids is related to the decrease in the risk of UC.
    However, high intake of docosahexaenoic acid, eicosapentaenoic acid and docosapentaenoic acid may increase the risk of UC.

          This study confirmed that the increase in the intake of n-3 / n-6 polyunsaturated fatty acids is related to the decrease in the risk of UC.
    However, high intake of docosahexaenoic acid, eicosapentaenoic acid and docosapentaenoic acid may increase the risk of UC.

     

     

     

    Original source:

    Yumie Kobayashi.
    Et al.
    oup.
    com/ibdjournal/article-abstract/27/5/617/5854441?redirectedFrom=fulltext" target="_blank" rel="noopener">Association of Dietary Fatty Acid Intake With the Development of Ulcerative Colitis: A Multicenter Case-Control Study in Japan.
    Inflammatory Bowel Diseases.
    oup.
    com/ibdjournal/article-abstract/27/5/617/5854441?redirectedFrom=fulltext" target="_blank" rel="noopener">2021 .

    oup.
    com/ibdjournal/article-abstract/27/5/617/5854441?redirectedFrom=fulltext" target="_blank" rel="noopener">Association of Dietary Fatty Acid Intake With the Development of Ulcerative Colitis: A Multicenter Case-Control Study in Japan.

     



    Leave a message here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.
    Related Articles

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent Echemi's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.