Identification of important molecules related to brain function recovery

Identification of important molecules related to brain function recovery

Determination of important molecules related to the recovery of brain function Determination of important molecules related to the recovery of brain function

Science and Technology Daily, Beijing, June 7 (intern reporter Zhang Jiaxin) A new study by the Neuroscience Initiative Team of the Advanced Science Research Center of the Graduate School of the State University of New York found that a molecule called TET1 is an essential part of myelin repair
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The study, published in the 7th "Nature Communications" suggests, TET1 can be modified to the NPC DNA specific brain glial cells can form new myelin to deal with myelin damage

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Recent studies have shown that due to injuries, physical exercise and mental stimulation, the human body forms new brain cells every day
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Glial cells, especially those called oligodendrocyte progenitor cells, are highly sensitive to external signals and damage

Myelin sheath is a membrane that wraps around the axons of nerve cells and provides metabolic support and accurate electrical signal transmission
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However, as we age, there is less and less myelin formed in response to external signals.

"We designed experiments to identify molecules that may affect the rejuvenation of the brain
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" The lead author of the study and assistant professor of the team Sara Moyen said, "We found that TET1 levels in old mice gradually decreased.

Combined with whole-genome sequencing bioinformatics, the authors show that the DNA modification induced by TET1 in young mice is essential to promote healthy dialogue between cells in the central nervous system and ensure normal function
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The researchers said that the newly discovered age-related decline in TET1 may explain the failure of the elderly to form new myelin
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Studying the effect of glial cell aging on patients with neurodegenerative diseases under normal circumstances will ultimately help scientists design better treatment strategies to slow the progression of destructive diseases such as multiple sclerosis and Alzheimer's.

Researchers say this discovery may also have important implications for the molecular regeneration of the aging brains of healthy individuals
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Currently, research aimed at increasing TET1 levels in aged mice is underway to determine whether this molecule can help form new myelin sheaths and promote proper glial cell communication