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    Home > Active Ingredient News > Antitumor Therapy > IJC: Data from over 600,000 women reveal the relationship between adult weight changes and premenopausal breast cancer risk

    IJC: Data from over 600,000 women reveal the relationship between adult weight changes and premenopausal breast cancer risk

    • Last Update: 2021-09-12
    • Source: Internet
    • Author: User
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    The effect of obesity on breast cancer risk varies with age.


    The effect of obesity on breast cancer risk varies with age.


    The analysis included 628,463 women with a median age of 39.


    The analysis included 628,463 women with a median age of 39.






    Women who lost more than 5 kg of weight after 18-24 years of age had a significantly lower risk of breast cancer compared with women who maintained the same weight


    In these models, the association between initial weight and risk is still statistically significant


    In terms of breast cancer invasiveness, the negative correlation between weight gain and the risk of breast cancer is often more obvious in carcinoma in situ than in invasive carcinoma, but only between 18-24 and 25-34 years old (p-interaction = 0.


    In the analysis of breast cancer subtypes, weight gain over the age of 18-24 was negatively correlated with Luminal A-like (ER+PR+HER2 -) breast cancer and weight gain.


    We have observed that weight loss ≥5 kg and weight gain ≥10-15 kg in early adulthood are negatively associated with the


    This result may help understand the cause of breast cancer and help risk stratification


     



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