Immune globulin IgA or can target the body of a special microbiome of patients with inflammatory bowel disease

The pathogenesis of inflammatory bowel disease (IBD, inflammatory bowel disease) is thought to be the result of a combination of host genetic factors and intestinal ecological imbalances, and previous studies of a small number of IBD patients have shown that inflammatory bacterial groups are often highly covered by the secretional immunoglobulin IgA. in the
study, researchers used bacterial fluorescence-activated cell sequencing technology in conjunction with 16S rRNA gene sequencing (IgA-SEQ) to analyze the coverage of intestinal microbes in the body of a larger cohort of IBD patients, and identified specific bacteria associated with disease and therapy.
researchers found that 43 bacterial groups showed significantly higher levels of IGA coverage compared to the controls, eight of which showed different IgA coverage, but with similar abundance.
Compared to the control group, patients treated with anti-TNF-α therapy tended to exhibit significantly altered microbial-specific IgA responses;
addition, the research highlights include: 1) the researchers used IGA-SEQ technology to evaluate a large number of IBD patients with IgA-covered bacterial community; IBD-related bacterial community;3) patients treated with anti-INF-α therapy were able to exhibit a specific IgA response to microbial changes; 4) IgA-covered envelopes of bacteria belonging to the genus Helicobacterium were directly related to delays in surgery time in IBD patients.
original source: Jason M. Shapiro, Marcel R.de Zoete, Noah W. Palm, et al. Immunoglobulin A Targets a Unique Subset of the Microbiota in Inflammatory Bowel Disease, Cell Host & Microbe (2020) doi:10.1016/j.chom.2020.12.003。