Immunity: COVID-19 human brain tissue analysis reveals the interaction between neuroinflammation and microglia-T cells

COVID-19 caused by SARS-CoV-2 is a serious disease that can cause multiple organ complications.

COVID-19 caused by SARS-CoV-2 is a serious disease that can cause multiple organ complications.

Picture source: https://doi.

COVID-19 can cause severe neurological symptoms, but its underlying pathophysiological mechanism is unclear

Image source: https://doi.

Picture source: https://doi.

This article analyzes the cellular composition and immune phenotype of the central nervous tissue of patients who died of COVID-19 and found that a deep immune activation controlled by CD8 + T cell clusters affects blood vessels and cell-microglia crosstalk.

Picture source: https://doi.

Considering the principle of immune activation in the brain of COVID-19 , researchers want to know whether this powerful immune activation mode in the brainstem is related to tissue destruction and neuronal damage

Picture source: https://doi.

To understand the pathophysiology of immune and COVID-19 process, the paper studies the brain depth analysis of immune parameters high spatial correlation analysis , found between the specific anatomical compartments and a plurality of specific immune cell clusters relates checkpoints and Disease-related CD8 T cell-microglia crosstalk is a possible therapeutic molecular target in the future

references

references

Marius Schwabenland et al.
Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T cell interactions.
Immunity (2021) doi: https://doi.
org/10.
1016/j.
immuni.
2021.
06.
002

Marius Schwabenland et al.
Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T cell interactions.
Immunity (2021) doi: https://doi.
org/10.
1016/j.
immuni.
2021.
06.
002 Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T cell interactions.